Liver Conditions
http://hdl.handle.net/20.500.12904/105
2024-03-28T14:08:51Z
2024-03-28T14:08:51Z
Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial
Jones, Katy A.
Rennick-Egglestone, Stefan
http://hdl.handle.net/20.500.12904/14982
2022-10-03T10:11:11Z
2021-01-01T00:00:00Z
Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial
Jones, Katy A.; Rennick-Egglestone, Stefan
INTRODUCTIONHeavy drinkers in contact with alcohol services do not routinely have access to testing to establish the severity of potential liver disease. Transient elastography by FibroScan can provide this information. A recent systematic review suggested providing feedback to patients based on markers of liver injury can be an effective way to reduce harmful alcohol intake. This randomised control trial (RCT) aims to establish the feasibility of conducting a larger national trial to test the effectiveness of FibroScan advice and Alcohol Recovery Video Stories (ARVS) in changing high-risk drinking behaviour in community alcohol services common to UK practice.METHODS AND ANALYSISThis feasibility trial consists of three work packages (WP). WP1: To draft a standardised script for FibroScan operators to deliver liver disease-specific advice to eligible participants having FibroScan. WP2: To create a video library of ARVS for use in the feasibility RCT (WP3). WP3: To test the feasibility of the trial design, including the FibroScan script and video stories developed in WP1 and WP2 in a one-to-one individual randomised trial in community alcohol services. Semi-structured interviews will be conducted at 6 months follow-up for qualitative evaluation. Outcomes will be measures of the feasibility of conducting a larger RCT. These outcomes will relate to: participant recruitment and follow-up, intervention delivery, including the use of the Knowledge of LIver Fibrosis Affects Drinking trial FibroScan scripts and videos, clinical outcomes, and the acceptability and experience of the intervention and trial-related procedures. Data analysis will primarily be descriptive to address the feasibility aims of the trial. All proposed analyses will be documented in a Statistical Analysis Plan.ETHICS AND DISSEMINATIONThis trial received favourable ethical approval from the West of Scotland Research Ethics Service (WoSRES) on 20 January 2021, REC reference: 20/WS/0179. Results will be submitted for publication to a peer-reviewed journal.TRIAL REGISTRATION NUMBERISRCTN16922410.
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/
This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
2021-01-01T00:00:00Z
Mental health and hepatitis C
Alvey, Richard
Holmes, Mark
http://hdl.handle.net/20.500.12904/11744
2023-10-06T08:44:51Z
2017-01-01T00:00:00Z
Mental health and hepatitis C
Alvey, Richard; Holmes, Mark
Richard Alvey, Cognitive Behavioural Therapist, and Mark Holmes, Head of Education, both at Institute of Mental Health, Nottinghamshire Healthcare NHS Trust, discuss addressing the mind–liver relationship in hepatitis services
2017-01-01T00:00:00Z
Tears and laughter in the hall: Hearing the human story
Holmes, Mark
http://hdl.handle.net/20.500.12904/11743
2023-10-06T08:44:51Z
2017-01-01T00:00:00Z
Tears and laughter in the hall: Hearing the human story
Holmes, Mark
The article discusses the need to bring the voice of service users into nursing presentations in England.
2017-01-01T00:00:00Z
Are strategies on alcohol-related liver disease just talk?
Holmes, Mark
http://hdl.handle.net/20.500.12904/11742
2023-10-06T08:44:51Z
2016-01-01T00:00:00Z
Are strategies on alcohol-related liver disease just talk?
Holmes, Mark
The author reflects on progress on strategies on dealing with alcohol-related liver disease, as of June 2016. He recounts a local Public Health England liver event where he reflected on liver disease. He mentions reports about liver disease including "Measuring the Units: A Review of Patients Who Died With Alcohol-Related Liver Disease." He also cites the Alcohol Concern's Blue Light Project which highlights the interventions that can be made to work with change- resistant drinkers.
2016-01-01T00:00:00Z