Show simple item record

dc.contributor.authorMohamed, Ahmed
dc.contributor.authorJames, Cathryn
dc.contributor.authorAmer, Saad
dc.date.accessioned2018-03-20T16:05:17Z
dc.date.available2018-03-20T16:05:17Z
dc.date.issued2017-07
dc.identifier.citationActa Obstet Gynecol Scand. 2017 Jul;96(7):795-803. doi: 10.1111/aogs.13133. Epub 2017 May 4.en
dc.identifier.urihttp://hdl.handle.net/20.500.12904/1156
dc.descriptionAuthor(s) Pre Print Version Only. 12 Month Embargo on Post Print. No PDFen
dc.description.abstractINTRODUCTION: Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. MATERIAL AND METHODS: A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154). RESULTS: Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, -0.10 ng/mL; 95% CI -0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, -0.11 ng/mL; 95% CI -0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants' age (<40 years) still showed no statistically significant changes in circulating AMH. CONCLUSION: Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain.en
dc.language.isoenen
dc.subjectAnti-Mullerian Hormoneen
dc.subjectLaparoscopyen
dc.subjectOvarian Functionen
dc.subjectOvarian Reserveen
dc.subjectSalpingectomyen
dc.titleOvarian reserve after salpingectomy: a systematic review and meta-analysis.en
dc.typeArticleen


This item appears in the following Collection(s)

Show simple item record