Ovarian reserve after salpingectomy: a systematic review and meta-analysis.
dc.contributor.author | Mohamed, Ahmed | |
dc.contributor.author | James, Cathryn | |
dc.contributor.author | Amer, Saad | |
dc.date.accessioned | 2018-03-20T16:05:17Z | |
dc.date.available | 2018-03-20T16:05:17Z | |
dc.date.issued | 2017-07 | |
dc.identifier.citation | Acta Obstet Gynecol Scand. 2017 Jul;96(7):795-803. doi: 10.1111/aogs.13133. Epub 2017 May 4. | en |
dc.identifier.uri | http://hdl.handle.net/20.500.12904/1156 | |
dc.description | Author(s) Pre Print Version Only. 12 Month Embargo on Post Print. No PDF | en |
dc.description.abstract | INTRODUCTION: Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. MATERIAL AND METHODS: A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154). RESULTS: Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, -0.10 ng/mL; 95% CI -0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, -0.11 ng/mL; 95% CI -0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants' age (<40 years) still showed no statistically significant changes in circulating AMH. CONCLUSION: Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain. | en |
dc.language.iso | en | en |
dc.subject | Anti-Mullerian Hormone | en |
dc.subject | Laparoscopy | en |
dc.subject | Ovarian Function | en |
dc.subject | Ovarian Reserve | en |
dc.subject | Salpingectomy | en |
dc.title | Ovarian reserve after salpingectomy: a systematic review and meta-analysis. | en |
dc.type | Article | en |