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dc.contributor.authorGroom, Madeleine J.
dc.date.accessioned2017-08-24T14:27:42Z
dc.date.available2017-08-24T14:27:42Z
dc.date.issued2014
dc.identifier.citationPremjumar, P., Espirito-Santo, M., Onwumere, J., Kumari, V., Groom, M. J., and Kuiper, E. (2014). Greater leftward frontal alpha activation during criticism is associated with schizotypal traits and anxiety. In: Nasrallah, H. A. & DeLisi, L. E., (Eds.) 4th Biennial Schizophrenia International Research Conference, 5-9 April 2014 Florence, Italy. Amsterdam: Schizophrenia Research, p.S155.
dc.identifier.other10.1016/s0920-9964(14)70460-8
dc.identifier.urihttp://hdl.handle.net/20.500.12904/14149
dc.description.abstractBackground: Criticism from a caregiver predicts relapse, longer hospitalization and greater symptom severity in schizophrenia. Characterised by its tone and content, criticism may be seen as a standardised construct that elicits a specific neural response in those perceiving it. fMRI research indicates that listening to criticism activates the superior frontal gyrus in patients with schizophrenia a d individuals with high schizotypy. Greater anxiety is associated with greater superior-to-middle frontal gyral connectivity during standardized criticism. The electrocortical response to insult is increased leftward frontal alpha (alpha) activation. The study aimed to determine the relation between leftward frontal alpha activation during standardised criticism and schizotypy, anxiety and criticism from a close relative. Methods: Twenty-two healthy individuals (mean age=23 years; range 18-40 years; 15 women) underwent electroencephalography (EEG) while listening to a standard set of comments (criticism, positive and neutral comments) spoken in a male or female voice and imagining them to be spoken by a close relative. Ten of these participants (7 women; 3 men) were also assessed on schizotypy and anxiety. Their close relative (6 partners, 3 siblings, 1 parent) was assessed on Expressed Emotion (a standard measure of criticism) using the Camberwell Family Interview. The absolute spectral power during the comment and event-related synchronization/desynchronization (ERS/ERD) within 500ms epochs of the comment in the low (8-10Hz) and high (10-12 Hz) alpha frequency bands were extracted in the middle-lateral (F3, F4, FC3, FC4) and lateral frontal sites (F5, FC5, F6, FC6). Asymmetry was calculated by subtracting spectral power in the left from right hemisphere electrodes. Analysis of variance was performed followed by post hoc paired-sample t-tests. Planned Spearman correlations were performed between spectral power, schizotypy, anxiety and carer criticism. Results: Three out of ten participants had a high EE relative. Participants, on average, had low positive schizotypy (mean number of unusual experiences= 3.7, range 0-7). At the F3/F4, an emotion-by by-hemisphere-gender interaction in low alpha-activation was explained by greater activation during female criticism than neutral comments. At F5/F6, a main effect of emotion in high alpha-activation revealed more activation during male criticism than neutral comments. At FC3/FC4, an emotion-by-hemisphere-by-gender interaction in low alpha ERS/ERD showed greater ERS during female criticism and positive comments than neutral comments at the 0-500ms epoch. Greater impulsive non-conformity and anxiety correlated with lower leftward low alpha-activation at F3/F4 sites during female criticism. More relative criticism correlated with greater leftward high alpha-activation at F5/F6 sites during male positive comments. Greater introvertive anhedonia correlated with lower leftward FC5/FC6 ERS/ERD asymmetry at 0-500ms during female positive comments. Discussion: Greater frontal alpha-activation during criticism than neutral comments suggests greater cognitive appraisal of criticism, with low alpha-activation indicating greater general attention and high alpha-activation indicating greater semantic processing. The inverse association between leftward frontal alpha-activation during criticism and schizotypy and anxiety suggests increasing withdrawal from and emotional reactivity to criticism. However, more criticism from predominantly low-EE relatives was associated with greater leftward frontal high alpha-activation during positive comments. This finding indicates greater 'approach motivation', i.e. both heightened attention to, and more evaluation of positive comments.
dc.description.urihttp://www.schres-journal.com/article/S0920-9964(14)70460-8/abstract
dc.subjectCaregivers
dc.subjectElectroencephalography
dc.subjectEmotions
dc.titleGreater leftward frontal alpha activation during criticism is associated with schizotypal traits and anxiety
dc.typeConference Proceeding


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