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    Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication

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    Author
    Finlayson-Burden, Jodie M.
    Keyword
    Obsessive-compulsive disorder
    Corpus striatum
    Occipital lobe
    Parietal lobe
    Date
    2012
    
    Metadata
    Show full item record
    DOI
    10.1371/journal.pone.0035889
    Publisher's URL
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035889
    Abstract
    Background: Abnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. Objective: To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. Methodology and Principal Findings: Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were acquired from 27 unmedicated OCD patients (including 13 drug-naive individuals) and 23 healthy controls. Voxel-based analysis was then performed to detect regions with significant group difference. We compared the DTI-derived parameters of 15 patients before and after 12-week Selective Serotonin Reuptake Inhibitor (SSRI) therapies. Significant differences of DTI-derived parameters were observed between OCD and healthy groups in multiple structures, mainly within the fronto-striato-thalamo-cortical loop. An increased RD in combination with no change in AD among OCD patients was found in the left medial superior frontal gyrus, temporo-parietal lobe, occipital lobe, striatum, insula and right midbrain. There was no statistical difference in DTI-derived parameters between drug-naive and previously medicated OCD patients. After being medicated, OCD patients showed a reduction in RD of the left striatum and right midbrain, and in MD of the right midbrain. Conclusion: Our preliminary findings suggest that abnormalities of white matter microstructure, particularly in terms of myelin integrity, are primari ly located within the fronto-striato-thalamo-cortical circuit of individuals with OCD. Some abnormalities may be partly reversed by SSRI treatment. © 2012 Fan et al.
    Citation
    Fan, Q., Yan, X., Wang, J., Chen, Y., Wang, X., Li, C., Tan, L., You, C., Zhang, T., Zuo, S., et al. (2012). Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication. PLoS ONE, 7 (4), pp.e35889.
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/14153
    Note
    © 2012 Fan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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