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dc.contributor.authorFinlayson-Burden, Jodie M.
dc.date.accessioned2017-08-24T14:27:23Z
dc.date.available2017-08-24T14:27:23Z
dc.date.issued2012
dc.identifier.citationFan, Q., Yan, X., Wang, J., Chen, Y., Wang, X., Li, C., Tan, L., You, C., Zhang, T., Zuo, S., et al. (2012). Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication. PLoS ONE, 7 (4), pp.e35889.
dc.identifier.other10.1371/journal.pone.0035889
dc.identifier.urihttp://hdl.handle.net/20.500.12904/14153
dc.description© 2012 Fan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractBackground: Abnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. Objective: To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. Methodology and Principal Findings: Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were acquired from 27 unmedicated OCD patients (including 13 drug-naive individuals) and 23 healthy controls. Voxel-based analysis was then performed to detect regions with significant group difference. We compared the DTI-derived parameters of 15 patients before and after 12-week Selective Serotonin Reuptake Inhibitor (SSRI) therapies. Significant differences of DTI-derived parameters were observed between OCD and healthy groups in multiple structures, mainly within the fronto-striato-thalamo-cortical loop. An increased RD in combination with no change in AD among OCD patients was found in the left medial superior frontal gyrus, temporo-parietal lobe, occipital lobe, striatum, insula and right midbrain. There was no statistical difference in DTI-derived parameters between drug-naive and previously medicated OCD patients. After being medicated, OCD patients showed a reduction in RD of the left striatum and right midbrain, and in MD of the right midbrain. Conclusion: Our preliminary findings suggest that abnormalities of white matter microstructure, particularly in terms of myelin integrity, are primari ly located within the fronto-striato-thalamo-cortical circuit of individuals with OCD. Some abnormalities may be partly reversed by SSRI treatment. © 2012 Fan et al.
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035889
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dc.subjectObsessive-compulsive disorder
dc.subjectCorpus striatum
dc.subjectOccipital lobe
dc.subjectParietal lobe
dc.titleAbnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication
dc.typeArticle
refterms.dateFOA2021-06-16T19:37:08Z


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