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    COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies

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    Author
    das Nair, Roshan
    Keyword
    COVID-19
    SARS-CoV-2
    Telecommunications
    Multiple sclerosis
    Surveys and questionnaires
    Date
    2021
    
    Metadata
    Show full item record
    DOI
    10.1016/j.msard.2021.102939
    Publisher's URL
    https://www.msard-journal.com/article/S2211-0348(21)00206-6/abstract#%20
    Abstract
    Background: Infections can trigger exacerbations of multiple sclerosis (MS). The effects of the coronavirus disease 2019 (COVID-19) on MS are not known. The aim of this study was to understand the impact of COVID-19 on new and pre-existing symptoms of MS.
    Method(s): The COVID-19 and MS study is an ongoing community-based, prospective cohort study conducted as part of the United Kingdom MS Register. People with MS and COVID-19 were invited by email to complete a questionnaire about their MS symptoms during the infection. An MS exacerbation was defined as developing new MS symptoms and/or worsening of pre-existing MS symptoms.
    Result(s): Fifty-seven percent (230/404) of participants had an MS exacerbation during their infection; 82 developed new MS symptoms, 207 experienced worsened pre-existing MS symptoms, and 59 reported both. Disease modifying therapies (DMTs) reduced the likelihood of developing new MS symptoms during the infection (OR 0.556, 95%CI 0.316-0.978). Participants with a higher pre-COVID-19 webEDSS (web-based Expanded Disability Status Scale) score (OR 1.251, 95%CI 1.060-1.478) and longer MS duration (OR 1.042, 95%CI 1.009-1.076) were more likely to experience worsening of their pre-existing MS symptoms during the infection.
    Conclusion(s): COVID-19 infection was associated with exacerbation of MS. DMTs reduced the chance of developing new MS symptoms during the infection.
    Copyright © 2021 IS - 2211-0348 EN - 2211-0356 DO - http://dx.doi.org/10.1016/j.msard.2021.102939
    Citation
    Garjani, A., Middleton, R. M., Hunter, R., Tuite-Dalton, K. A., Coles, A., Dobson, R., Duddy, M., Hughes, S., Pearson, O. R., Rog, D., et al. (2021). COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies. Multiple Sclerosis and Related Disorders, 52, pp.102939.
    URI
    http://hdl.handle.net/20.500.12904/14756
    Collections
    COVID-19
    Neurological Conditions

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