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    Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders

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    Author
    Katshu, Mohammad Z.
    Liddle, Peter F.
    Keyword
    Psychosis
    Schizophrenia
    Antipsychotic agents
    Date
    2021
    
    Metadata
    Show full item record
    DOI
    10.3389/fpsyt.2021.703452
    Publisher's URL
    https://www.frontiersin.org/articles/10.3389/fpsyt.2021.703452/full
    Abstract
    Schizophrenia is associated with increased levels of oxidative stress, as reflected by an increase in the concentrations of damaging reactive species and a reduction in anti-oxidant defences to combat them. Evidence has suggested that whilst not the likely primary cause of schizophrenia, increased oxidative stress may contribute to declining course and poor outcomes associated with schizophrenia. Here we discuss how oxidative stress may be implicated in the aetiology of schizophrenia and examine how current understanding relates associations with symptoms, potentially via lipid peroxidation induced neuronal damage. We argue that oxidative stress may be a good target for future pharmacotherapy in schizophrenia and suggest a multi-step model of illness progression with oxidative stress involved at each stage.
    Citation
    Murray, A. J., Rogers, J. C., Katshu, M. Z., Liddle, P. F. & Upthegrove, R. (2021). Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders. Frontiers in Psychiatry, 12, pp.703452.
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/14841
    Collections
    Psychosis and Schizophrenia

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