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dc.contributor.authorKatshu, Mohammad Z.
dc.contributor.authorLiddle, Peter F.
dc.date.accessioned2021-08-18T10:15:14Z
dc.date.available2021-08-18T10:15:14Z
dc.date.issued2021
dc.identifier.citationMurray, A. J., Rogers, J. C., Katshu, M. Z., Liddle, P. F. & Upthegrove, R. (2021). Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders. Frontiers in Psychiatry, 12, pp.703452.en_US
dc.identifier.other10.3389/fpsyt.2021.703452
dc.identifier.urihttp://hdl.handle.net/20.500.12904/14841
dc.description.abstractSchizophrenia is associated with increased levels of oxidative stress, as reflected by an increase in the concentrations of damaging reactive species and a reduction in anti-oxidant defences to combat them. Evidence has suggested that whilst not the likely primary cause of schizophrenia, increased oxidative stress may contribute to declining course and poor outcomes associated with schizophrenia. Here we discuss how oxidative stress may be implicated in the aetiology of schizophrenia and examine how current understanding relates associations with symptoms, potentially via lipid peroxidation induced neuronal damage. We argue that oxidative stress may be a good target for future pharmacotherapy in schizophrenia and suggest a multi-step model of illness progression with oxidative stress involved at each stage.
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.703452/full
dc.language.isoenen_US
dc.subjectPsychosisen_US
dc.subjectSchizophreniaen_US
dc.subjectAntipsychotic agentsen_US
dc.titleOxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disordersen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.panelUnspecifieden_US
html.description.abstractSchizophrenia is associated with increased levels of oxidative stress, as reflected by an increase in the concentrations of damaging reactive species and a reduction in anti-oxidant defences to combat them. Evidence has suggested that whilst not the likely primary cause of schizophrenia, increased oxidative stress may contribute to declining course and poor outcomes associated with schizophrenia. Here we discuss how oxidative stress may be implicated in the aetiology of schizophrenia and examine how current understanding relates associations with symptoms, potentially via lipid peroxidation induced neuronal damage. We argue that oxidative stress may be a good target for future pharmacotherapy in schizophrenia and suggest a multi-step model of illness progression with oxidative stress involved at each stage.en_US
dc.description.urlhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.703452/fullen_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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