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    The utility of Magnetoencephalography in multiple sclerosis – A systematic review

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    Author
    Sami, Musa
    Keyword
    Multiple sclerosis
    Magnetoencephalography
    Cognition
    Date
    2021
    
    Metadata
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    DOI
    10.1016/j.nicl.2021.102814
    Publisher's URL
    https://www.sciencedirect.com/science/article/pii/S2213158221002588
    Abstract
    Introduction Magnetoencephalography (MEG), allows for a high degree temporal and spatial accuracy in recording cortical oscillatory activity and evoked fields. To date, no review has been undertaken to synthesise all MEG studies in Multiple Sclerosis (MS). We undertook a Systematic Review of the utility of MEG in MS. Methods We identified MEG studies carried out in MS using EMBASE, Medline, Cochrane, TRIP and Psychinfo databases. We included original research articles with a cohort of minimum of five multiple sclerosis patients and quantifying of at least one MEG parameter. We used a modified version of the JBI (mJBI) for case-control studies to assess for risk of bias. Results We identified 30 studies from 13 centres involving at least 433 MS patients and 347 controls. We found evidence that MEG shows perturbed activity (most commonly reduced power modulations), reduced connectivity and association with altered clinical function in Multiple Sclerosis. Specific replicated findings were decreased motor induced responses in the beta band, diminished increase of gamma power after visual stimulation, increased latency and reduced connectivity for somatosensory evoked fields. There was an association between upper alpha connectivity and cognitive measures in people with MS. Overall studies were of moderate quality (mean mJBI score 6.7). Discussion We find evidence for the utility of MEG in Multiple Sclerosis. Event-related designs are of particular value and show replicability between centres. At this stage, it is not clear whether these changes are specific to Multiple Sclerosis or are also observable in other diseases. Further studies should look to explore cognitive control in more depth using in-task designs and undertake longitudinal studies to determine whether these changes have prognostic value.
    Citation
    Khan, H., Sami, M. & Litvak, V. (2021). The utility of Magnetoencephalography in multiple sclerosis – A systematic review. NeuroImage: Clinical, 32, pp.102814.
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/14888
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    Neurological Conditions

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