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    Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study

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    Author
    Walsh, David A
    Keyword
    Knee pain
    Risk factors
    Cohort
    Incidence
    Osteoarthritis
    Date
    2018-11
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.oarsijournal.com/article/S1063-4584(18)31388-8/fulltext
    Abstract
    Aim: To explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms. Methods: A questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a month. Baseline prevalence, and one year incidence and progression (KP worsening) were examined. Central (e.g., Pain Catastrophizing Scale (PCS)) and peripheral (e.g., significant injury) risk factors were examined. Adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression. Proportional risk contribution (PRC) was estimated using receiver-operator-characteristic (ROC) analysis. Results: Of 9506 baseline participants, 4288 (45%) had KP (men 1826; women, 2462). KP incidence was 12% (men 11%, women 13%), and KP progression 19% (men 16%, women 21%) at one year. While both central and peripheral factors contributed to prevalence, central factors contributed more to progression, and peripheral factors more to incidence of KP. For example, although PCS (OR 2.06, 95% CI 1.88-2.25) and injury (5.62, 4.92-6.42) associated with KP prevalence, PCS associated with progression (2.27, 1.83-2.83) but not incidence (1.14, 0.86-1.52), whereas injury more strongly associated with incidence (69.27, 24.15-198.7) than progression (2.52, 1.48-4.30). The PRC of central and peripheral factors were 19% and 23% for prevalence, 14% and 29% for incidence, and 29% and 5% for progression, respectively. Conclusions: Both central and peripheral risk factors influence KP but relative contributions may differ in terms of development (mainly peripheral) and progression (mainly central). Further study of such relative contributions may inform primary and secondary prevention strategies.
    Citation
    Sarmanova, A. et al. (2018) ‘Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study’, Osteoarthritis and Cartilage, 26(11), pp. 1461–1473
    Publisher
    Osteoarthritis and Cartilage
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/14938
    Collections
    Rheumatology

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