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dc.contributor.authorWalsh, David A
dc.date.accessioned2021-11-05T10:58:31Z
dc.date.available2021-11-05T10:58:31Z
dc.date.issued2018-10
dc.identifier.citationAshraf, S. et al. (2018) ‘Effects of carrageenan induced synovitis on joint damage and pain in a rat model of knee osteoarthritis’, Osteoarthritis and Cartilage, 26(10), pp. 1369–1378en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12904/14963
dc.description.abstractObjective: Knee osteoarthritis (OA) is associated with ongoing pain and joint damage that can be punctuated by acute flares of pain and inflammation. Synovitis in normal knees might resolve without long-term detriment to joint function. We hypothesised that osteoarthritis is associated with impaired resilience to inflammatory flares. Design: We induced synovitis by injecting carrageenan into rat knees with or without meniscal transection (MNX)-induced OA, and measured synovitis, weightbearing asymmetry (pain behaviour), and joint damage up to 35 days after OA induction (23 days after carrageenan-injection). Results: Carrageenan injection induced weightbearing asymmetry for 1 week, transient increase in knee diameter for 2 days, and a sustained increase in synovial macrophages, endothelial cell proliferation and vascular density compared with naive vehicle-injected controls. MNX surgery induced weightbearing asymmetry and histological evidence of OA. Carrageenan-injection in MNX-operated knees was followed for 2 days by increased weightbearing asymmetry compared either to MNX+vehicle or to sham+carrageenan groups. OA structural damage and synovitis at day 35 were greater in MNX+carrageenan compared to MNX+vehicle and sham+carrageenan groups. Carrageenan injection did not induce OA in Sham-operated knees. Conclusion: Intra-articular injection of the pro-inflammatory compound carrageenan in OA and sham-operated control knees induced a short term increase in joint pain. Even though pain flares resolved in both groups and damage was not induced in sham-operated knees, carrageen injection exacerbated long-term joint damage in OA knees. OA knees display less resilience to inflammatory episodes. Preventing inflammatory flares may be particularly important in preventing symptoms and long term joint damage in OA.
dc.description.urihttps://www.oarsijournal.com/article/S1063-4584(18)31360-8/fulltexten_US
dc.publisherOsteoarthritis and Cartilageen_US
dc.subjectOsteoarthritisen_US
dc.subjectInflammationen_US
dc.subjectPainen_US
dc.subjectAnimal modelsen_US
dc.subjectSynoviumen_US
dc.subjectCarrageenanen_US
dc.titleEffects of carrageenan induced synovitis on joint damage and pain in a rat model of knee osteoarthritisen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecord10.1016/j.joca.2018.07.001en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFOA2021-11-05T10:58:31Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2018-07
html.description.abstractObjective: Knee osteoarthritis (OA) is associated with ongoing pain and joint damage that can be punctuated by acute flares of pain and inflammation. Synovitis in normal knees might resolve without long-term detriment to joint function. We hypothesised that osteoarthritis is associated with impaired resilience to inflammatory flares. Design: We induced synovitis by injecting carrageenan into rat knees with or without meniscal transection (MNX)-induced OA, and measured synovitis, weightbearing asymmetry (pain behaviour), and joint damage up to 35 days after OA induction (23 days after carrageenan-injection). Results: Carrageenan injection induced weightbearing asymmetry for 1 week, transient increase in knee diameter for 2 days, and a sustained increase in synovial macrophages, endothelial cell proliferation and vascular density compared with naive vehicle-injected controls. MNX surgery induced weightbearing asymmetry and histological evidence of OA. Carrageenan-injection in MNX-operated knees was followed for 2 days by increased weightbearing asymmetry compared either to MNX+vehicle or to sham+carrageenan groups. OA structural damage and synovitis at day 35 were greater in MNX+carrageenan compared to MNX+vehicle and sham+carrageenan groups. Carrageenan injection did not induce OA in Sham-operated knees. Conclusion: Intra-articular injection of the pro-inflammatory compound carrageenan in OA and sham-operated control knees induced a short term increase in joint pain. Even though pain flares resolved in both groups and damage was not induced in sham-operated knees, carrageen injection exacerbated long-term joint damage in OA knees. OA knees display less resilience to inflammatory episodes. Preventing inflammatory flares may be particularly important in preventing symptoms and long term joint damage in OA.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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