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    Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis

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    Author
    Walsh, David A
    Keyword
    TRAcP5b
    Subchondral bone
    Biomarker
    Osteoarthritis pain
    Osteoclast
    Date
    2017-06
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.sciencedirect.com/science/article/pii/S1063458417300092
    Abstract
    Summary Objectives To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K (cath-K), indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Results Serum TRAcP5b activity, but not cath-K-immunoreactivity, was associated with density of TRAcP-positive osteoclasts in the subchondral bone of medial tibia plateaux. TRAcP-positive osteoclasts were more abundant in people with symptomatic OA compared to controls. Serum TRAcP5b activity was associated with baseline pain and pain change. Conclusions Our observations support a role for subchondral osteoclast activity in the generation of OA pain. Serum TRAcP5b might be a clinically relevant biomarker of disease activity in OA.
    Citation
    Nwosu, L. N. et al. (2017) ‘Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA’, Osteoarthritis and Cartilage, 25(6), pp. 858–865.
    Publisher
    Osteoarthritis and Cartilage
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/14970
    Collections
    Rheumatology

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