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dc.contributor.authorWalsh, David A
dc.date.accessioned2021-11-10T10:29:55Z
dc.date.available2021-11-10T10:29:55Z
dc.date.issued2017-06
dc.identifier.citationNwosu, L. N. et al. (2017) ‘Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA’, Osteoarthritis and Cartilage, 25(6), pp. 858–865.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12904/14970
dc.description.abstractSummary Objectives To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K (cath-K), indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Results Serum TRAcP5b activity, but not cath-K-immunoreactivity, was associated with density of TRAcP-positive osteoclasts in the subchondral bone of medial tibia plateaux. TRAcP-positive osteoclasts were more abundant in people with symptomatic OA compared to controls. Serum TRAcP5b activity was associated with baseline pain and pain change. Conclusions Our observations support a role for subchondral osteoclast activity in the generation of OA pain. Serum TRAcP5b might be a clinically relevant biomarker of disease activity in OA.
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S1063458417300092en_US
dc.publisherOsteoarthritis and Cartilageen_US
dc.subjectTRAcP5ben_US
dc.subjectSubchondral boneen_US
dc.subjectBiomarkeren_US
dc.subjectOsteoarthritis painen_US
dc.subjectOsteoclasten_US
dc.titlePain prediction by serum biomarkers of bone turnover in people with knee osteoarthritisen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecord10.1016/j.joca.2017.01.002en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFOA2021-11-10T10:29:56Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2017-01
html.description.abstractSummary Objectives To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K (cath-K), indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Results Serum TRAcP5b activity, but not cath-K-immunoreactivity, was associated with density of TRAcP-positive osteoclasts in the subchondral bone of medial tibia plateaux. TRAcP-positive osteoclasts were more abundant in people with symptomatic OA compared to controls. Serum TRAcP5b activity was associated with baseline pain and pain change. Conclusions Our observations support a role for subchondral osteoclast activity in the generation of OA pain. Serum TRAcP5b might be a clinically relevant biomarker of disease activity in OA.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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