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    Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

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    Author
    Walsh, David A
    Keyword
    Knee OA
    Monosodium iodoacetate
    Pain behaviour
    Structural pathology
    Synovitis
    Date
    2016-11
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.oarsijournal.com/article/S1063-4584(16)30144-3/fulltext
    Abstract
    Objectives: To address the hypothesis that different types of established osteoarthritis (OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosodium iodoacetate (MIA) in the rat. Methods: Rats received a single intra-articular injection of 0.1 mg or 1 mg MIA or saline (control). Pain behaviour (hind limb weight bearing asymmetry (WB) and hindpaw withdrawal threshold (PWT) to punctate stimulation) was assessed. Cartilage and synovium were examined by macroscopic visualisation of articular surfaces and histopathology. Results: Both doses of MIA lowered PWTs, 1 mg MIA also resulted in WB asymmetry. Both doses were associated with cartilage macroscopic appearance, proteoglycan loss, abnormal chondrocyte morphology, increased numbers of vessels crossing the osteochondral junction, synovitis and macrophage infiltration into the synovium. PWTs were more strongly associated with chondrocyte morphology, synovitis and macrophage infiltration than with loss of cartilage surface integrity. Conclusions: Both pain behaviours were associated with OA structural severity and synovitis. Differences in pain phenotype following low vs higher dose of MIA were identified despite similar structural pathology. OA structural pathology as traditionally measured only partially explains the MIA-induced pain phenotype.
    Citation
    Nwosu, L. et al. (2016) Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis Cartilage. 2016 Jun 24. pii: S1063-4584(16)30144-3
    Publisher
    Osteoarthritis and Cartilage
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/14972
    Collections
    Rheumatology

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