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    Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999-2002

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    Author
    Stephan, Blossom C. M.
    Keyword
    Obesity
    Muscular atrophy
    Date
    2021
    
    Metadata
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    DOI
    10.1038/s41366-021-00995-z
    Publisher's URL
    https://www.nature.com/articles/s41366-021-00995-z
    Abstract
    Sarcopenic obesity (SO) is characterised by the concurrent presence of sarcopenia and excess adiposity. Telomere shortening has been associated with sarcopenia and obesity alone but the association between SO and telomere length (TL) has not been investigated. This study aimed to investigate SO and TL in an adult population. Data were from 5397 individuals (mean age = 44.7 years, 51.3% male) enrolled in the National Health and Nutrition Examination Survey. Body composition (BC) was assessed by Dual Energy X-Ray Absorptiometry. Two models were used to assess SO: a BC model including four phenotypes derived from the combination of high or low adiposity and muscle mass; and, a truncal fat mass to appendicular skeletal mass ratio (TrFM/ASM). TL was assessed using quantitative polymerase chain reaction and expressed as base pairs. The mean TL, relative to the reference DNA, was calculated and expressed as the mean T/S ratio. A General Linear Model was applied to determine associations between TL for SO. In adjusted analysis, only individuals with SO, defined as the presence of high adiposity-low muscle mass (four-phenotype model), had significantly shorter telomeres (p = 0.05) than the reference group (i.e. low adiposity-high muscle mass), with a mean T/S ratio of 1.02 (95%CI: 0.98–1.05) compared to 1.05 (95%CI: 1.01–1.09), respectively. TrFM/ASM was not associated with TL. Preliminary findings suggest that sarcopenia and obesity may act synergistically to shorten telomeres.
    Citation
    Goddard, T., Tsintzas, K., Stephan, B. C. M., Prado, C. M., Mazidi, M. & Siervo, M. (2021). Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002. International Journal of Obesity, 46, pp. 437-440.
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15008
    Collections
    Diet, Nutrition and Obesity

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