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dc.contributor.authorMarsh, Anna-Marie
dc.contributor.authorSamani, Nilesh
dc.contributor.authorMcCann, Gerry
dc.contributor.authorAdlam, David
dc.contributor.authorChung, Emma
dc.contributor.authorRamnarine, Kumar
dc.date.accessioned2022-01-26T12:47:17Z
dc.date.available2022-01-26T12:47:17Z
dc.date.issued2022
dc.identifier.citationAl-Mutairi, F. F., Al-Hussaini, A., Marsh, A. M., Samani, N., McCann, G., Adlam, D., Chung, E., & Ramnarine, K. V. (2022). Ultrasound shear wave elastography imaging of common carotid arteries in patients with Spontaneous Coronary Artery Dissection (SCAD). Journal of ultrasound, 10.1007/s40477-021-00627-2. Advance online publication. https://doi.org/10.1007/s40477-021-00627-2en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15108
dc.description.abstractBackground: Shear wave elastography (SWE) is emerging as a valuable clinical tool for a variety of conditions. The aim of this pilot study was to assess the potential of SWE imaging of the common carotid arteries (CCA) in patients with spontaneous coronary artery dissection (SCAD), a rare but potentially life-threatening condition, hypothesized to be linked to changes in vessel wall elasticity. Methods: Ultrasound shear wave elastography (SWE) estimates of artery wall elasticity were obtained from the left and right CCAs of 89 confirmed SCAD patients and 38 non-dissection controls. SWE images obtained over multiple cardiac cycles were analysed by a blinded observer to estimate elasticity in the form of a Young's Modulus (YM) value, across regions of interest (ROI) located within the anterior and posterior CCA walls. Results: YM estimates ranged from 17 to 133 kPa in SCAD patients compared to 34 to 87 kPa in non-dissection controls. The mean YM of 55 [standard deviation (SD): 21] kPa in SCAD patients was not significantly different to the mean of 57 [SD: 12] kPa in controls, p = 0.32. The difference between groups was 2 kPa [95% Confidence Interval - 11, 4]. Conclusions: SWE imaging of CCAs in SCAD patients is feasible although the clinical benefit is limited by relatively high variability of YM values which may have contributed to our finding of no significant difference between SCAD patients and non-dissection controls.
dc.description.sponsorshipThis project was funded by the Deanship of Scientific Research (DSR) at King Abdul-Aziz University, Jeddah, under grant no. D-241-142-1443. The authors, therefore, acknowledge with thanks DSR for technical and financial support. This study was supported by the British Heart Foundation (BHF) PG/13/96/30608, the NIHR rare disease translational collaboration, the Leicester NIHR Biomedical Research Centre and BeatSCAD.en_US
dc.description.urihttps://link.springer.com/article/10.1007%2Fs40477-021-00627-2en_US
dc.language.isoenen_US
dc.subjectcarotid arteryen_US
dc.subjectspontaneous coronary artery dissectionen_US
dc.subjectstiffnessen_US
dc.subjectultrasound shear wave elastographyen_US
dc.subjectYoung’s modulusen_US
dc.titleUltrasound shear wave elastography imaging of common carotid arteries in patients with Spontaneous Coronary Artery Dissection (SCAD)en_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecordhttps://doi.org/10.1007/s40477-021-00627-2en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFCD2022-01-26T12:47:17Z
refterms.versionFCDVoR
refterms.dateFOA2022-01-26T12:47:18Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2022
html.description.abstractBackground: Shear wave elastography (SWE) is emerging as a valuable clinical tool for a variety of conditions. The aim of this pilot study was to assess the potential of SWE imaging of the common carotid arteries (CCA) in patients with spontaneous coronary artery dissection (SCAD), a rare but potentially life-threatening condition, hypothesized to be linked to changes in vessel wall elasticity. Methods: Ultrasound shear wave elastography (SWE) estimates of artery wall elasticity were obtained from the left and right CCAs of 89 confirmed SCAD patients and 38 non-dissection controls. SWE images obtained over multiple cardiac cycles were analysed by a blinded observer to estimate elasticity in the form of a Young's Modulus (YM) value, across regions of interest (ROI) located within the anterior and posterior CCA walls. Results: YM estimates ranged from 17 to 133 kPa in SCAD patients compared to 34 to 87 kPa in non-dissection controls. The mean YM of 55 [standard deviation (SD): 21] kPa in SCAD patients was not significantly different to the mean of 57 [SD: 12] kPa in controls, p = 0.32. The difference between groups was 2 kPa [95% Confidence Interval - 11, 4]. Conclusions: SWE imaging of CCAs in SCAD patients is feasible although the clinical benefit is limited by relatively high variability of YM values which may have contributed to our finding of no significant difference between SCAD patients and non-dissection controls.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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