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    Delineating the Smith-Kingsmore syndrome phenotype: Investigation of 16 patients with the MTOR c.5395G > A p.(Glu1799Lys) missense variant

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    Author
    Searle, Claire
    Vasudevan, Pradeep
    Keyword
    MTOR
    Smith-Kingsmore syndrome
    megalencephaly
    Date
    2021
    
    Metadata
    Show full item record
    Publisher's URL
    https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.62350
    Abstract
    Smith-Kingsmore Syndrome (SKS) is a rare genetic syndrome associated with megalencephaly, a variable intellectual disability, autism spectrum disorder, and MTOR gain of function variants. Only 30 patients with MTOR missense variants are published, including 14 (47%) with the MTOR c.5395G>A p.(Glu1799Lys) variant. Limited phenotypic data impacts the quality of information delivered to families and the robustness of interpretation of novel MTOR missense variation. This study aims to improve our understanding of the SKS phenotype through the investigation of 16 further patients with the MTOR c.5395G>A p.(Glu1799Lys) variant. Through the careful phenotypic evaluation of these 16 patients and integration with data from 14 previously reported patients, we have defined major (100% patients) and frequent (>15%) SKS clinical characteristics and, using these data, proposed guidance for evidence-based management. In addition, in the absence of functional studies, we suggest that the combination of the SKS major clinical features of megalencephaly (where the head circumference is at least 3SD) and an intellectual disability with a de novo MTOR missense variant (absent from population databases) should be considered diagnostic for SKS.
    Citation
    Poole, R. L., Curry, P., Marcinkute, R., Brewer, C., Coman, D., Hobson, E., Johnson, D., Lynch, S. A., Saggar, A., Searle, C., Scurr, I., Turnpenny, P. D., Vasudevan, P., & Tatton-Brown, K. (2021). Delineating the Smith-Kingsmore syndrome phenotype: Investigation of 16 patients with the MTOR c.5395G > A p.(Glu1799Lys) missense variant. American journal of medical genetics. Part A, 185(8), 2445–2454. https://doi.org/10.1002/ajmg.a.62350
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15125
    Collections
    Genetics

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