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dc.contributor.authorRobinson, Thompson
dc.contributor.authorMinhas, Jatinder
dc.date.accessioned2022-03-03T15:55:10Z
dc.date.available2022-03-03T15:55:10Z
dc.identifier.citationRobinson, T. G., Minhas, J. S., & Miller, J. (2022). Review of major trials of acute blood pressure management in stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 42(3), 404–410.en_US
dc.identifier.otherdoi.org/10.1177/0271678X211004310
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15209
dc.description.abstractOver the last two decades, there have been a number of major landmark clinical trials, classified as "major" as they sought to address clear clinical practice driven questions, in a pragmatic yet robust trial design, using a large powered sample size (n > 1000), in order to help improve patient outcome through informing guidelines. A commonality across all stroke sub-types included in these trials is the tendency to acute hypertensive crises within the acute stroke period. This phenomenon is associated with greater stroke complications and worsened overall prognosis. Multiple trials have attempted to address the issue of acute blood pressure management during the acute stroke period, with consideration for timing, magnitude of lowering, agent and relationship to other interventions. This review will consider the major clinical trials performed in ischaemic and haemorrhagic stroke that test the hypothesis that acute BP reduction improves clinical outcomes.
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851668/en_US
dc.description.urihttps://journals.sagepub.com/doi/10.1177/0271678X211004310en_US
dc.language.isoenen_US
dc.subjectBlood pressureen_US
dc.subjectHypertensionen_US
dc.subjectStrokeen_US
dc.subjectIntracerebral haemorrhageen_US
dc.titleReview of major trials of acute blood pressure management in strokeen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.panelUnspecifieden_US
html.description.abstractOver the last two decades, there have been a number of major landmark clinical trials, classified as "major" as they sought to address clear clinical practice driven questions, in a pragmatic yet robust trial design, using a large powered sample size (n > 1000), in order to help improve patient outcome through informing guidelines. A commonality across all stroke sub-types included in these trials is the tendency to acute hypertensive crises within the acute stroke period. This phenomenon is associated with greater stroke complications and worsened overall prognosis. Multiple trials have attempted to address the issue of acute blood pressure management during the acute stroke period, with consideration for timing, magnitude of lowering, agent and relationship to other interventions. This review will consider the major clinical trials performed in ischaemic and haemorrhagic stroke that test the hypothesis that acute BP reduction improves clinical outcomes.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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