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dc.contributor.authorMcQueen, Liam
dc.contributor.authorLadak, Shameem
dc.contributor.authorZakkar, Mustafa
dc.date.accessioned2022-03-11T10:58:22Z
dc.date.available2022-03-11T10:58:22Z
dc.date.issued2022
dc.identifier.citationMcQueen, L. W., Ladak, S. S., & Zakkar, M. (2022). Acute shear stress and vein graft disease. The international journal of biochemistry & cell biology, 144, 106173. https://doi.org/10.1016/j.biocel.2022.106173en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15243
dc.description.abstractThe long saphenous vein is commonly used in cardiac surgery to bypass occluded coronary arteries. Its use is complicated by late stenosis and occlusion due to the development of intimal hyperplasia. It is accepted that intimal hyperplasia is a multifactorial inflammatory process that starts immediately after surgery. The role of acute changes in haemodynamic conditions when the vein is implanted into arterial circulation, especially shear stress, is not fully appreciated. This review provides an overview of intimal hyperplasia and the effect of acute shear stress changes on the activation of pro-inflammatory mediators.
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S1357272522000188?via%3Dihuben_US
dc.subjectintimal hyperplasiaen_US
dc.subjectshear stressen_US
dc.subjectvascular inflammationen_US
dc.subjectvein graftsen_US
dc.titleAcute shear stress and vein graft diseaseen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.biocel.2022.106173en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2022
html.description.abstractThe long saphenous vein is commonly used in cardiac surgery to bypass occluded coronary arteries. Its use is complicated by late stenosis and occlusion due to the development of intimal hyperplasia. It is accepted that intimal hyperplasia is a multifactorial inflammatory process that starts immediately after surgery. The role of acute changes in haemodynamic conditions when the vein is implanted into arterial circulation, especially shear stress, is not fully appreciated. This review provides an overview of intimal hyperplasia and the effect of acute shear stress changes on the activation of pro-inflammatory mediators.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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