• Login
    View Item 
    •   Home
    • University Hospitals of Leicester NHS Trust
    • Renal, Respiratory and Cardiovascular
    • Cardiology
    • View Item
    •   Home
    • University Hospitals of Leicester NHS Trust
    • Renal, Respiratory and Cardiovascular
    • Cardiology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of EMERCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjectsProfilesView

    My Account

    LoginRegister

    Links

    About EMERPoliciesDerbyshire Community Health Services NHS Foundation TrustLeicester Partnership TrustNHS Nottingham and Nottinghamshire CCGNottinghamshire Healthcare NHS Foundation TrustNottingham University Hospitals NHS TrustSherwood Forest Hospitals NHS Foundation TrustUniversity Hospitals of Derby and Burton NHS Foundation TrustUniversity Hospitals Of Leicester NHS TrustOther Resources

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Prospective longitudinal characterization of the relationship between diabetes and cardiac structural and functional changes

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Athithan, Lavanya
    Keyword
    diabetes
    type 2 diabetes
    cardiac MRI
    heart disease
    major adverse cardiovascular events
    Date
    2022
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.hindawi.com/journals/crp/2022/6401180/
    Abstract
    Objectives: In a cohort of type 2 diabetic (T2D) patients who underwent baseline cardiac magnetic resonance (CMR) and biomarker testing, during a median follow-up of 6 years, we aimed to determine longitudinal changes in the phenotypic expression of heart disease in diabetes, report clinical outcomes, and compare baseline clinical characteristics and CMR findings of patients who experienced major adverse cardiovascular events (MACE) to those remaining MACE free. Background: T2D increases the risk of heart failure (HF) and cardiovascular mortality. The long-term impact of T2D on cardiac phenotype in the absence of cardiovascular disease and other clinical events is unknown. Methods: Patients with T2D (n = 100) with no history of cardiovascular disease or hypertension were recruited at baseline. Biventricular volumes, function, and myocardial extracellular volume fraction (ECV) were assessed by CMR, and blood biomarkers were taken. Follow-up CMR was repeated in those without interim clinical events after 6 years. Results: Follow-up was successful in 83 participants. Of those, 29 experienced cardiovascular/clinical events (36%). Of the remaining 59, 32 patients who experienced no events received follow-up CMR. In this cohort, despite no significant changes in blood pressure, weight, or glycated hemoglobin, significant reductions in biventricular end-diastolic volumes and ejection fractions occurred over time. The mean ECV was unchanged. Baseline plasma high-sensitivity cardiac troponin T (hs-cTnT) was significantly associated with a change in left ventricular (LV) ejection fraction. Patients who experienced MACE had higher LV mass and greater LV concentricity than those who remained event free. Conclusions: T2D results in reductions in biventricular size and systolic function over time even in the absence of cardiovascular/clinical events.
    Citation
    Chowdhary, A., Jex, N., Thirunavukarasu, S., MacCannell, A., Haywood, N., Almutairi, A., Athithan, L., Jain, M., Craven, T., Das, A., Sharrack, N., Saunderson, C., Sengupta, A., Roberts, L., Swoboda, P., Cubbon, R., Witte, K., Greenwood, J., Plein, S., & Levelt, E. (2022). Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes. Cardiology research and practice, 2022, 6401180. https://doi.org/10.1155/2022/6401180
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15260
    Collections
    Diabetology
    Cardiology

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.