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dc.contributor.authorWalsh, David A
dc.date.accessioned2022-04-25T12:49:18Z
dc.date.available2022-04-25T12:49:18Z
dc.date.issued2012-05
dc.identifier.citationWalsh, D. A. et al. (2012) ‘Lymphatic vessels in osteoarthritic human knees’, Osteoarthritis and Cartilage, 20(5), pp. 405–412.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15368
dc.description.abstractSummary Objectives The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely. This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic parameters in osteoarthritis (OA). Results Lymphatic vessels were present in synovia from both disease groups, but were not identified in subchondral bone. Synovial lymphatic densities were independent of radiological severity and age. Synovia from patients with OA displayed lower LVD (z=−3.4, P=0.001) and lower LEC fractional areas (z=−4.5, P<0.0005) than non-arthritic controls. In patients with OA, low LVD was associated with clinically detectable effusion (z=−2.2, P=0.027), but not with histological evidence of synovitis. The negative associations between lymphatics and OA/effusion appeared to be independent of other measured confounders. Conclusion Lymphatic vessels are present in lower densities in OA synovia. Abnormalities of synovial fluid drainage may confound the value of effusion as a clinical sign of synovitis in OA.
dc.description.urihttps://www.oarsijournal.com/article/S1063-4584(12)00036-2/fulltexten_US
dc.publisherOsteoarthritis and Cartilageen_US
dc.subjectLymphatic vesselsen_US
dc.subjectOsteoarthritisen_US
dc.subjectEffusionen_US
dc.subjectSynoviumen_US
dc.subjectBoneen_US
dc.titleLymphatic vessels in osteoarthritic human kneesen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecord10.1016/j.joca.2012.01.012en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFOA2022-04-25T12:49:19Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2012-01
html.description.abstractSummary Objectives The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely. This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic parameters in osteoarthritis (OA). Results Lymphatic vessels were present in synovia from both disease groups, but were not identified in subchondral bone. Synovial lymphatic densities were independent of radiological severity and age. Synovia from patients with OA displayed lower LVD (z=−3.4, P=0.001) and lower LEC fractional areas (z=−4.5, P<0.0005) than non-arthritic controls. In patients with OA, low LVD was associated with clinically detectable effusion (z=−2.2, P=0.027), but not with histological evidence of synovitis. The negative associations between lymphatics and OA/effusion appeared to be independent of other measured confounders. Conclusion Lymphatic vessels are present in lower densities in OA synovia. Abnormalities of synovial fluid drainage may confound the value of effusion as a clinical sign of synovitis in OA.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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