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    An evaluation of the strengths and weaknesses of a register of early Rheumatoid Arthritis

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    Author
    Walsh, David A
    Keyword
    Rheumatoid arthritis
    RA outcomes
    Disease registry
    DMARDs
    Date
    2011-01
    
    Metadata
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    Publisher's URL
    https://academic.oup.com/rheumatology/article/50/1/176/1790552
    Abstract
    Objectives: To evaluate the strengths and weaknesses of a register of management and outcomes of recently diagnosed RA, and allow comparisons between rheumatology centres on good clinical practice and guidelines. Methods: A register of newly diagnosed RA was initiated in 1986 in nine different regions of England, later expanded to UK-wide membership in 2002. Standardized data collection includes disease activity, function, radiological damage, therapy, hospitalizations, major comorbidity and mortality. A centralized database generates individual reports and comparative data for each centre yearly. Aims have been compared with actual achievements and any changes over 25 years. Results: Thirty rheumatology centres have recruited 2866 patients. Study outputs have included peer-reviewed scientific publications and contributions to the recent National Audit Office report on RA. Referral times into secondary care have changed little over 25 years, but time to initiation of drug therapies has decreased. Delays between publication of clinical trial evidence and management guidelines and their implementation in normal clinical practice are illustrated by relatively infrequent use of combination therapies at diagnosis. Consecutive case recruitment, centre participation and follow-up were reportedly compromised by local funding issues. Centre participants report a benefit from feedback of actual clinical practice compared with recommended standards of care. Conclusions: Most of the original objectives have been achieved. Cohort studies based predominantly in District General Hospitals provide unique insights into the natural history and impact of RA, its management, the translation of research findings into clinical practice and provide participating centres with important clinical governance and professional development opportunities.
    Citation
    Young, A. et al. (2011) ‘An evaluation of the strengths and weaknesses of a register of newly diagnosed rheumatoid arthritis, 1986-2010’, Rheumatology (Oxford, England), 50(1), pp. 176–183
    Publisher
    Rheumatology (Oxford)
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15378
    Collections
    Rheumatology

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