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    Injectable semaglutide and reductions in HbA1c and weight in the real-world in people switched from alternative glucagon-like peptide 1 receptor agonists.

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    Author
    Crabtree, Thomas
    Idris, Iskandar
    Keyword
    GLP-1 Analogue
    Observational Study
    Type 2 Diabetes
    
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    Abstract
    The ABCD semaglutide audit was designed to capture the routine clinical outcomes of people commenced on semaglutide in the UK. Previous work demonstrated differential reductions in HbA1c and weight dependent on previous GLPRA exposure. The analysis, in this research letter, demonstrates decreases in HbA1c and weight associated with semaglutide occur irrespective of previous GLP1RA use. However, HbA1c reductions were less if switched from dulaglutide or liraglutide and weight changes were attenuated if switched from dulaglutide or exenatide - potentially suggesting differing potencies between GLP1RAs. Dedicated studies with head-to-head comparisons are needed to confirm these findings. This article is protected by copyright. All rights reserved.
    Citation
    Diabetes Obes Metab. 2022 Mar 23. doi: 10.1111/dom.14701. Online ahead of print.
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15412
    Collections
    Specialist Medicine

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