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    Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis

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    Author
    Walsh, David A
    Keyword
    Articular cartilage
    Avascular
    Aneural
    Neurovascular
    Osteoarthritis
    Date
    2007-11
    
    Metadata
    Show full item record
    Publisher's URL
    https://ard.bmj.com/content/66/11/1423.long
    Abstract
    Background: Normal adult articular cartilage is thought to be avascular and aneural. Objective: To describe neurovascular structures at the osteochondral junction and in osteophytes in tibiofemoral osteoarthritis (OA) displaying a range of severity of cartilage changes. Methods: Articular surfaces were obtained from 40 patients at total knee joint replacement surgery for tibiofemoral OA (TKR) and seven patients post mortem (PM). Antibodies directed against CD34 (vascular endothelium), protein gene product 9.5 (pan-neuronal marker), substance P and calcitonin gene-related peptide (sensory nerves) and C-flanking peptide of neuropeptide Y (sympathetic nerves) were used to localise blood vessels and nerves by immunohistochemistry. Severity of OA cartilage changes was graded histologically. Results: TKR and PM samples displayed a range of OA cartilage changes including tidemark breaching by vascular channels. Sympathetic and sensory nerves were both present within vascular channels in the articular cartilage, in both mild and severe OA. Perivascular and free nerve fibres, and nerve trunks were observed within the subchondral bone marrow and within the marrow cavities of osteophytes. Sensory and sympathetic nerves displayed similar distributions in each region studied. Conclusion: Vascularisation and the associated innervation of articular cartilage may contribute to tibiofemoral pain in OA across a wide range of structural disease severity.
    Citation
    Suri, S. et al. (2007) ‘Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis’, ANNALS OF THE RHEUMATIC DISEASES, 1 January, pp. 1423–1428
    Publisher
    Annals of the Rheumatic Diseases
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15429
    Collections
    Rheumatology

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