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    Central pain processing in osteoarthritis; implications for treatment

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    Author
    Walsh, David A
    Keyword
    Physiological aspects
    Care and treatment
    Osteoarthritis
    Pain
    Date
    2014-01
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.futuremedicine.com/doi/epub/10.2217/pmt.13.64
    Abstract
    Osteoarthritis (OA) is a major cause of pain and is characterized by loss of articular cartilage integrity, synovitis and remodeling of subchondral bone. However, OA pain mechanisms remain incompletely understood. Pain severity does not always correlate with the extent of joint damage. Furthermore, many people with OA continue to experience pain despite optimal use of standard therapies that target the joints, including joint-replacement surgery. There is compelling evidence that altered central pain processing plays an important role in maintaining pain and increasing pain severity in some people with OA. A key challenge is to identify this subgroup of patients with abnormal central pain processing in order to improve their clinical outcomes by developing and targeting specific analgesic treatments.
    Citation
    Hassan, H. and Walsh, D. A. (2014) ‘Central pain processing in osteoarthritis: implications for treatment’, Pain Management, 4(1), p. 45
    Publisher
    Pain Management
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15563
    Collections
    Rheumatology

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