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dc.contributor.authorWalsh, David A
dc.date.accessioned2022-05-31T13:08:42Z
dc.date.available2022-05-31T13:08:42Z
dc.date.issued2014-01
dc.identifier.citationHassan, H. and Walsh, D. A. (2014) ‘Central pain processing in osteoarthritis: implications for treatment’, Pain Management, 4(1), p. 45en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15563
dc.description.abstractOsteoarthritis (OA) is a major cause of pain and is characterized by loss of articular cartilage integrity, synovitis and remodeling of subchondral bone. However, OA pain mechanisms remain incompletely understood. Pain severity does not always correlate with the extent of joint damage. Furthermore, many people with OA continue to experience pain despite optimal use of standard therapies that target the joints, including joint-replacement surgery. There is compelling evidence that altered central pain processing plays an important role in maintaining pain and increasing pain severity in some people with OA. A key challenge is to identify this subgroup of patients with abnormal central pain processing in order to improve their clinical outcomes by developing and targeting specific analgesic treatments.
dc.description.urihttps://www.futuremedicine.com/doi/epub/10.2217/pmt.13.64en_US
dc.publisherPain Managementen_US
dc.subjectPhysiological aspectsen_US
dc.subjectCare and treatmenten_US
dc.subjectOsteoarthritisen_US
dc.subjectPainen_US
dc.titleCentral pain processing in osteoarthritis; implications for treatmenten_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecord10.2217/pmt.13.64en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.panelUnspecifieden_US
html.description.abstractOsteoarthritis (OA) is a major cause of pain and is characterized by loss of articular cartilage integrity, synovitis and remodeling of subchondral bone. However, OA pain mechanisms remain incompletely understood. Pain severity does not always correlate with the extent of joint damage. Furthermore, many people with OA continue to experience pain despite optimal use of standard therapies that target the joints, including joint-replacement surgery. There is compelling evidence that altered central pain processing plays an important role in maintaining pain and increasing pain severity in some people with OA. A key challenge is to identify this subgroup of patients with abnormal central pain processing in order to improve their clinical outcomes by developing and targeting specific analgesic treatments.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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