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    Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials

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    Author
    Walsh, David A
    Keyword
    Capsaicin
    n-of-1
    Osteoarthritis
    Response
    Topical NSAID
    Date
    2021-05
    
    Metadata
    Show full item record
    Publisher's URL
    https://academic.oup.com/rheumatology/article/60/5/2231/5983716
    Abstract
    Objectives: To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials. Methods: Twenty-two participants were allocated 5% ibuprofen gel (A) and 0.025% capsaicin cream (B) in random sequence (AB or BA). Patients underwent up to 3 treatment cycles, each comprising one treatment for 4 weeks, an individualized washout period (maximum 4 weeks), then the other treatment for 4 weeks. Differential (ibuprofen or capsaicin) response was defined when change-from-baseline pain intensity scores (0-10 NRS) differed by ≥1 between treatments in ≥2 cycles within a participant. Results: A total of 104 treatment periods were aggregated. Mean pain reduction was 1.2 (95% CI: 0.5, 1.8) on ibuprofen and 1.6 (95% CI: 0.9, 2.4) on capsaicin (P = 0.221). Of 22 participants, 4 (18%) had a greater response to ibuprofen, 9 (41%) to capsaicin, 4 (18%) had similar responses, and 5 (23%) were undetermined. Conclusion: Irrespective of equal efficacy overall, 59% of people displayed a greater response to one treatment over the other. Patients who do not benefit from one type of topical treatment should be offered to try another, which may be more effective. N-of-1 trials are useful to identify individual response to treatment.
    Citation
    Persson, M. S. M. et al. (2021) ‘Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials’, Rheumatology, 60(5), pp. 2231–2237
    Publisher
    Rheumatology (Oxford)
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15582
    Collections
    Rheumatology

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