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    Thresholds of ultrasound synovial abnormalities for knee osteoarthritis - a cross sectional study in the general population

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    Author
    Walsh, David A
    Keyword
    Knee pain
    Osteoarthritis
    Synovitis
    Ultrasonography
    Ultrasound
    Date
    2019-03
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.oarsijournal.com/article/S1063-4584(18)31522-X/fulltext
    Abstract
    Objective: To establish "normal" ranges for synovial thickness and effusion detected by ultrasound (US) and to determine cut-offs associated with knee pain (KP) and radiographic knee osteoarthritis (RKOA) in the community. Methods: 147 women and 152 men ≥40 years old were randomly selected from the Nottingham KP and Related Health in the Community (KPIC) cohort (n = 9506). The "normal" range was established using the percentile method in 163 participants who had no KP and no RKOA. Optimal (maximum sensitivity and specificity) and high specificity (90%) cut-offs were established using receiver operating characteristic (ROC) curve analysis in a comparison between people with both KP and RKOA and normal controls. Results: Effusion and synovial hypertrophy differed by gender but not by age or laterality, therefore gender-specific reference limits were estimated. However, the "normal" ranges between men and women were similar for effusion (0-10.3 mm vs 0-9.8 mm), but different for synovial hypertrophy (0-6.8 mm vs 0-5.4 mm). Power Doppler Signal (PDS) in the healthy controls was uncommon (1.2% in men and 0.0% in women). The optimal cut-off was 7.4 mm for men and 5.3 mm for women for effusion, and 3.7 and 1.6 for hypertrophy respectively. The high specificity cut-off was 8.9 for men and 7.8 for women for effusion, and 5.8 and 4.2 for hypertrophy respectively. Conclusions: US effusion and synovial hypertrophy but not PDS are common, but differ by gender, in community-derived people without painful knee OA. Currently used cut-offs for abnormality need reappraisal.
    Citation
    Sarmanova, A. et al. (2019) ‘Thresholds of ultrasound synovial abnormalities for knee osteoarthritis -- a cross sectional study in the general population’, Osteoarthritis and Cartilage, 27(3), p. 435
    Publisher
    Osteoarthritis and Cartilage
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15592
    Collections
    Rheumatology

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