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dc.contributor.authorMartin, Christopher
dc.contributor.authorPatel, Prashanth
dc.contributor.authorGoss, Charles
dc.contributor.authorJenkins, David
dc.contributor.authorPrice, Arthur
dc.contributor.authorBarton, Linda
dc.contributor.authorGupta, Pankaj
dc.contributor.authorZaccardi, Francesco
dc.contributor.authorJerina, Helen
dc.contributor.authorDuraisingham, Sai
dc.contributor.authorBrunskill, Nigel
dc.contributor.authorPareek, Manish
dc.date.accessioned2022-07-05T15:12:07Z
dc.date.available2022-07-05T15:12:07Z
dc.identifier.citationMartin, C. A., Patel, P., Goss, C., Jenkins, D. R., Price, A., Barton, L., Gupta, P., Zaccardi, F., Jerina, H., Duraisingham, S., Brunskill, N. J., Khunti, K., & Pareek, M. (2022). Demographic and occupational determinants of anti-SARS-CoV-2 IgG seropositivity in hospital staff. Journal of public health (Oxford, England), 44(2), 234–245.en_US
dc.identifier.other0.1093/pubmed/fdaa199
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15631
dc.description.abstractBackground Although evidence suggests that demographic characteristics including minority ethnicity increase the risk of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), it is unclear whether these characteristics, together with occupational factors, influence anti-SARS-CoV-2 IgG seroprevalence in hospital staff. Methods We conducted cross-sectional surveillance examining seroprevalence of anti-SARS-CoV-2 IgG amongst staff at University Hospitals of Leicester (UHL) NHS Trust. We quantified seroprevalence stratified by ethnicity, occupation and seniority of practitioner and used logistic regression to examine demographic and occupational factors associated with seropositivity. Results A total of 1148/10662 (10.8%) hospital staff members were seropositive. Compared to White staff (seroprevalence 9.1%), seroprevalence was higher in South Asian (12.3%) and Black (21.2%) staff. The occupations and department with the highest seroprevalence were nurses/healthcare assistants (13.7%) and the Emergency Department (ED)/Acute Medicine (17.5%), respectively. Seroprevalence decreased with seniority in medical/nursing practitioners. Minority ethnicity was associated with seropositivity on an adjusted analysis (South Asian: aOR 1.26; 95%CI: 1.07–1.49 and Black: 2.42; 1.90–3.09). Anaesthetics/ICU staff members were less likely to be seropositive than ED/Acute medicine staff (0.41; 0.27–0.61). Conclusions Ethnicity and occupational factors, including specialty and seniority, are associated with seropositivity for anti-SARS-Cov-2 IgG. These findings could be used to inform occupational risk assessments for front-line healthcare workers.
dc.description.urihttps://academic.oup.com/jpubhealth/article/44/2/234/5983393en_US
dc.subjectCOVID-19en_US
dc.subjectEthnicityen_US
dc.subjectHealthcare workeren_US
dc.subjectSARS-COV-2en_US
dc.subjectSeroprevalenceen_US
dc.titleDemographic and occupational determinants of anti-SARS-CoV-2 IgG seropositivity in hospital staffen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecordhttps://doi.org/10.1093/pubmed/fdaa199en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2022-06-27
html.description.abstractBackground Although evidence suggests that demographic characteristics including minority ethnicity increase the risk of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), it is unclear whether these characteristics, together with occupational factors, influence anti-SARS-CoV-2 IgG seroprevalence in hospital staff. Methods We conducted cross-sectional surveillance examining seroprevalence of anti-SARS-CoV-2 IgG amongst staff at University Hospitals of Leicester (UHL) NHS Trust. We quantified seroprevalence stratified by ethnicity, occupation and seniority of practitioner and used logistic regression to examine demographic and occupational factors associated with seropositivity. Results A total of 1148/10662 (10.8%) hospital staff members were seropositive. Compared to White staff (seroprevalence 9.1%), seroprevalence was higher in South Asian (12.3%) and Black (21.2%) staff. The occupations and department with the highest seroprevalence were nurses/healthcare assistants (13.7%) and the Emergency Department (ED)/Acute Medicine (17.5%), respectively. Seroprevalence decreased with seniority in medical/nursing practitioners. Minority ethnicity was associated with seropositivity on an adjusted analysis (South Asian: aOR 1.26; 95%CI: 1.07–1.49 and Black: 2.42; 1.90–3.09). Anaesthetics/ICU staff members were less likely to be seropositive than ED/Acute medicine staff (0.41; 0.27–0.61). Conclusions Ethnicity and occupational factors, including specialty and seniority, are associated with seropositivity for anti-SARS-Cov-2 IgG. These findings could be used to inform occupational risk assessments for front-line healthcare workers.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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