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    Implementation of Whole-Body MRI (MY-RADS) within the OPTIMUM/MUKnine multi-centre clinical trial for patients with myeloma

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    Author
    Rennie, Winston
    Keyword
    DWI
    multi-centre clinical trial
    myeloma
    T1-w Dixon
    whole-body MRI
    Date
    2022-07
    
    Metadata
    Show full item record
    Publisher's URL
    https://insightsimaging.springeropen.com/articles/10.1186/s13244-022-01253-0
    Abstract
    Background: Whole-body (WB) MRI, which includes diffusion-weighted imaging (DWI) and T1-w Dixon, permits sensitive detection of marrow disease in addition to qualitative and quantitative measurements of disease and response to treatment of bone marrow. We report on the first study to embed standardised WB-MRI within a prospective, multi-centre myeloma clinical trial (IMAGIMM trial, sub-study of OPTIMUM/MUKnine) to explore the use of WB-MRI to detect minimal residual disease after treatment. Methods: The standardised MY-RADS WB-MRI protocol was set up on a local 1.5 T scanner. An imaging manual describing the MR protocol, quality assurance/control procedures and data transfer was produced and provided to sites. For non-identical scanners (different vendor or magnet strength), site visits from our physics team were organised to support protocol optimisation. The site qualification process included review of phantom and volunteer data acquired at each site and a teleconference to brief the multidisciplinary team. Image quality of initial patients at each site was assessed. Results: WB-MRI was successfully set up at 12 UK sites involving 3 vendor systems and two field strengths. Four main protocols (1.5 T Siemens, 3 T Siemens, 1.5 T Philips and 3 T GE scanners) were generated. Scanner limitations (hardware and software) and scanning time constraint required protocol modifications for 4 sites. Nevertheless, shared methodology and imaging protocols enabled other centres to obtain images suitable for qualitative and quantitative analysis. Conclusions: Standardised WB-MRI protocols can be implemented and supported in prospective multi-centre clinical trials. Trial registration NCT03188172 clinicaltrials.gov; registration date 15th June 2017 https://clinicaltrials.gov/ct2/show/study/NCT03188172.
    Citation
    Rata, M., Blackledge, M., Scurr, E., Winfield, J., Koh, D. M., Dragan, A., Candito, A., King, A., Rennie, W., Gaba, S., Suresh, P., Malcolm, P., Davis, A., Nilak, A., Shah, A., Gandhi, S., Albrizio, M., Drury, A., Roberts, S., Jenner, M., … Messiou, C. (2022). Implementation of Whole-Body MRI (MY-RADS) within the OPTIMUM/MUKnine multi-centre clinical trial for patients with myeloma. Insights into imaging, 13(1), 123. https://doi.org/10.1186/s13244-022-01253-0
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15709
    Collections
    Haematology

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