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    Radiomics in paediatric neuro-oncology: A multicentre study on MRI texture analysis

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    Author
    Rodriguez, Gutierrez D
    Auer, Dorothee P.
    Grundy, Richard
    Keyword
    Child
    Magnetic resonance imaging
    Neurology
    Radiation
    Date
    2018
    
    Metadata
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    Publisher's URL
    https://doi.org/10.1002/nbm.3781
    Abstract
    Brain tumours are the most common solid cancers in children in the UK and are the most common cause of cancer deaths in this age group. Despite current advances in MRI, non-invasive diagnosis of paediatric brain tumours has yet to find its way into routine clinical practice. Radiomics, the high-throughput extraction and analysis of quantitative image features (e.g. texture), offers potential solutions for tumour characterization and decision support. In the search for diagnostic oncological markers, the primary aim of this work was to study the application of MRI texture analysis (TA) for the classification of paediatric brain tumours. A multicentre study was carried out, within a supervised classification framework, on clinical MR images, and a support vector machine (SVM) was trained with 3D textural attributes obtained from conventional MRI. To determine the cross-centre transferability of TA, an assessment of how SVM performs on unseen datasets was carried out through rigorous pairwise testing. The study also investigated the nature of features that are most likely to train classifiers that can generalize well with the data. Finally, the issue of class imbalance, which arises due to some tumour types being more common than others, was explored. For each of the tests carried out through pairwise testing, the optimal area under the receiver operating characteristic curve ranged between 76% and 86%, suggesting that the model was able to capture transferable tumour information. Feature selection results suggest that similar aspects of tumour texture are enhanced by MR images obtained at different hospitals. Our results also suggest that the availability of equally represented classes has enabled SVM to better characterize the data points. The findings of the study presented here support the use of 3D TA on conventional MR images to aid diagnostic classification of paediatric brain tumours. Copyright © 2017 John Wiley & Sons, Ltd.
    Citation
    Fetit, A.E., Novak, J., Rodriguez, D., Auer, D.P., Clark, C.A., Grundy, R.G., Peet, A.C. and Arvanitis, T.N. (2018) 'Radiomics in paediatric neuro-oncology: A multicentre study on MRI texture analysis', NMR in biomedicine, 31(1). doi: https://dx.doi.org/10.1002/nbm.3781
    Publisher
    John Wiley and Sons Ltd
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15824
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

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