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    Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial

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    Author
    Rogers, Andy
    Akram, Perways
    Ravenscroft, Jane C
    Keyword
    Dermatologic agents
    Ultraviolet therapy
    Vitiligo
    Date
    2022
    
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    Publisher's URL
    https://dx.doi.org/10.1111/ced.15193
    Abstract
    BACKGROUND: The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better treatment response than potent TCS alone. However, it is unclear how to implement these findings., AIM: We sought to answer three questions: (i) Can combination treatment be used safely and effectively by people with vitiligo?; (ii) Should combination treatment be made available as routine clinical care?; and (iii) Can combination treatment be integrated within current healthcare provision?, METHODS: This was a mixed-methods process evaluation, including semi-structured interviews with a purposive sample of trial participants, structured interviews with commissioners, and an online survey and focus groups with trial staff. Transcripts were coded by framework analysis, with thematic development by multiple researchers., RESULTS: Participants found individual treatments easy to use, but the combination treatment was complicated and required nurse support. Both participants and site investigators felt that combination treatment should be made available, although commissioners were less certain. There was support for the development of services offering combination treatment, although this might not be prioritized above treatment for other conditions. A 'mixed economy' model was suggested, involving patients purchasing their own devices, although concerns regarding the safe use of treatments mean that training, monitoring and ongoing support are essential. The need for medical physics support may mean that a regional service is more practical., CONCLUSION: Combination treatment should be made available for people seeking treatment for vitiligo, but services require partnership with medical physics and ongoing training and support for patients. Copyright © 2022 The Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.
    Citation
    Leighton, P., Chalmers, J.R., Batchelor, J.M., Rogers, A., Akram, P., Haines, R.H., Meakin, G.D., White, J., Ravenscroft, J.C., Sach, T.H., Santer, M., Whitton, M.E., Eleftheriadou, V. and Thomas, K.S. (2022) 'Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial', Clinical and experimental dermatology, 47(8), pp. 1480-1489. doi: https://dx.doi.org/10.1111/ced.15193
    Publisher
    John Wiley and Sons Ltd
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15833
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

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