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    Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade

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    Author
    Morgan, Paul S
    Keyword
    Diffusion magnetic resonance imaging
    Glioma
    Preoperative care
    Date
    2018
    
    Metadata
    Show full item record
    Publisher's URL
    https://dx.doi.org/10.1016/j.clinimag.2018.07.005
    Abstract
    Preoperative identification of high-grade gliomas is critical to optimize treatment strategy and to predict prognosis. To determine whether perilesional apparent diffusion coefficient (ADC) values differ between high- and low-grade tumors, we assessed water diffusivity within normal-appearing brain parenchyma (NABP) surrounding gliomas in twenty-one treatment-naive patients. This showed significantly lower mean and 25th percentile (Q1) ADC values in high- grade compared to low-grade gliomas respectively in the range of 10-25 and 10-30mm away from combined tumor and surrounding T2 signal. Thus, perilesional ADC measurement may reflect the extent of tumor infiltration beyond the abnormality seen on conventional MRI. Copyright © 2018 Elsevier Inc. All rights reserved.
    Citation
    Yazdani, M., Rumboldt, Z., Tabesh, A., Giglio, P., Schiarelli, C., Morgan, P.S. and Spampinato, M.V. (2018) 'Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade', Clinical imaging, 52, pp. 88-94. doi: https://dx.doi.org/10.1016/j.clinimag.2018.07.005.
    Publisher
    Elsevier Ltd
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15841
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

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