Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade
| dc.contributor.author | Morgan, Paul S | |
| dc.date.accessioned | 2022-10-19T13:05:29Z | |
| dc.date.available | 2022-10-19T13:05:29Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Yazdani, M., Rumboldt, Z., Tabesh, A., Giglio, P., Schiarelli, C., Morgan, P.S. and Spampinato, M.V. (2018) 'Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade', Clinical imaging, 52, pp. 88-94. doi: https://dx.doi.org/10.1016/j.clinimag.2018.07.005. | en_US |
| dc.identifier.issn | 1873-4499 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12904/15841 | |
| dc.description.abstract | Preoperative identification of high-grade gliomas is critical to optimize treatment strategy and to predict prognosis. To determine whether perilesional apparent diffusion coefficient (ADC) values differ between high- and low-grade tumors, we assessed water diffusivity within normal-appearing brain parenchyma (NABP) surrounding gliomas in twenty-one treatment-naive patients. This showed significantly lower mean and 25th percentile (Q1) ADC values in high- grade compared to low-grade gliomas respectively in the range of 10-25 and 10-30mm away from combined tumor and surrounding T2 signal. Thus, perilesional ADC measurement may reflect the extent of tumor infiltration beyond the abnormality seen on conventional MRI. Copyright © 2018 Elsevier Inc. All rights reserved. | |
| dc.description.uri | https://dx.doi.org/10.1016/j.clinimag.2018.07.005 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd | en_US |
| dc.subject | Diffusion magnetic resonance imaging | en_US |
| dc.subject | Glioma | en_US |
| dc.subject | Preoperative care | en_US |
| dc.title | Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade | en_US |
| dc.type | Article | en_US |
| rioxxterms.funder | Default funder | en_US |
| rioxxterms.identifier.project | Default project | en_US |
| rioxxterms.version | VoR | en_US |
| rioxxterms.versionofrecord | 10.1016/j.clinimag.2018.07.005 | en_US |
| rioxxterms.type | Journal Article/Review | en_US |
| refterms.dateFCD | 2022-10-19T13:05:30Z | |
| refterms.versionFCD | VoR | |
| refterms.panel | Unspecified | en_US |
| refterms.dateFirstOnline | 2018 | |
| atmire.accessrights | ||
| html.description.abstract | Preoperative identification of high-grade gliomas is critical to optimize treatment strategy and to predict prognosis. To determine whether perilesional apparent diffusion coefficient (ADC) values differ between high- and low-grade tumors, we assessed water diffusivity within normal-appearing brain parenchyma (NABP) surrounding gliomas in twenty-one treatment-naive patients. This showed significantly lower mean and 25th percentile (Q1) ADC values in high- grade compared to low-grade gliomas respectively in the range of 10-25 and 10-30mm away from combined tumor and surrounding T2 signal. Thus, perilesional ADC measurement may reflect the extent of tumor infiltration beyond the abnormality seen on conventional MRI. Copyright © 2018 Elsevier Inc. All rights reserved. | en_US |
| rioxxterms.funder.project | 94a427429a5bcfef7dd04c33360d80cd | en_US |