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dc.contributor.authorParker, Helen
dc.contributor.authorHoad, Caroline L
dc.contributor.authorTucker, Emily
dc.contributor.authorCostigan, Carolyn
dc.contributor.authorMarciani, Luca
dc.contributor.authorFox, Mark
dc.date.accessioned2022-10-24T10:07:46Z
dc.date.available2022-10-24T10:07:46Z
dc.date.issued2018
dc.identifier.citationParker, H., Hoad, C.L., Tucker, E., Costigan, C., Marciani, L., Gowland, P. and Fox, M. (2018) 'Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects', Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 30(12), pp. e13463. doi: https://dx.doi.org/10.1111/nmo.13463.en_US
dc.identifier.issn1365-2982
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15860
dc.description.abstractBACKGROUND: Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs)., METHODS: The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads 0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emptying, contraction wave frequency, and secretion were obtained using validated methods., KEY RESULTS: Gastric function was measured in a population of 73 HVs stratified for age and sex. NTM induced moderate satiety and fullness. Labeled fluid was observed in the small bowel in all subjects after meal ingestion ("early-phase" GE). Secretion was rapid such that postprandial gastric content volume was often greater than meal volume (GCV0 > 400 mL), and there was increasing dilution of the meal during the study (P < 0.001). Gastric half-time was median 66-minutes (95% reference interval 35 to 161-minutes "late-phase" GE]). The number of intact agar beads in the stomach was 7/12 (58%) at 60-minutes and 1/12 (8%) at 120-minutes. Age, bodyweight and sex had measurable effects on gastric function; however, these were small compared to inter-individual variation for most metrics., CONCLUSIONS AND INFERENCES: Reference intervals are presented for MRI measurements of gastric function assessed for the mixed liquid/solid NTM. Studies in patients will determine which metrics are of clinical value and also whether the reference intervals presented here offer optimal diagnostic sensitivity and specificity. Copyright © 2018 John Wiley & Sons Ltd.
dc.description.urihttps://dx.doi.org/10.1111/nmo.13463en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.subjectGastric emptyingen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectStomachen_US
dc.titleGastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjectsen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1111/nmo.13463en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFCD2022-10-24T10:07:47Z
refterms.versionFCDVoR
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2018
html.description.abstractBACKGROUND: Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs)., METHODS: The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads 0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emptying, contraction wave frequency, and secretion were obtained using validated methods., KEY RESULTS: Gastric function was measured in a population of 73 HVs stratified for age and sex. NTM induced moderate satiety and fullness. Labeled fluid was observed in the small bowel in all subjects after meal ingestion ("early-phase" GE). Secretion was rapid such that postprandial gastric content volume was often greater than meal volume (GCV0 > 400 mL), and there was increasing dilution of the meal during the study (P < 0.001). Gastric half-time was median 66-minutes (95% reference interval 35 to 161-minutes "late-phase" GE]). The number of intact agar beads in the stomach was 7/12 (58%) at 60-minutes and 1/12 (8%) at 120-minutes. Age, bodyweight and sex had measurable effects on gastric function; however, these were small compared to inter-individual variation for most metrics., CONCLUSIONS AND INFERENCES: Reference intervals are presented for MRI measurements of gastric function assessed for the mixed liquid/solid NTM. Studies in patients will determine which metrics are of clinical value and also whether the reference intervals presented here offer optimal diagnostic sensitivity and specificity. Copyright © 2018 John Wiley & Sons Ltd.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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