Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects
dc.contributor.author | Parker, Helen | |
dc.contributor.author | Hoad, Caroline L | |
dc.contributor.author | Tucker, Emily | |
dc.contributor.author | Costigan, Carolyn | |
dc.contributor.author | Marciani, Luca | |
dc.contributor.author | Fox, Mark | |
dc.date.accessioned | 2022-10-24T10:07:46Z | |
dc.date.available | 2022-10-24T10:07:46Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Parker, H., Hoad, C.L., Tucker, E., Costigan, C., Marciani, L., Gowland, P. and Fox, M. (2018) 'Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects', Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 30(12), pp. e13463. doi: https://dx.doi.org/10.1111/nmo.13463. | en_US |
dc.identifier.issn | 1365-2982 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12904/15860 | |
dc.description.abstract | BACKGROUND: Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs)., METHODS: The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads 0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emptying, contraction wave frequency, and secretion were obtained using validated methods., KEY RESULTS: Gastric function was measured in a population of 73 HVs stratified for age and sex. NTM induced moderate satiety and fullness. Labeled fluid was observed in the small bowel in all subjects after meal ingestion ("early-phase" GE). Secretion was rapid such that postprandial gastric content volume was often greater than meal volume (GCV0 > 400 mL), and there was increasing dilution of the meal during the study (P < 0.001). Gastric half-time was median 66-minutes (95% reference interval 35 to 161-minutes "late-phase" GE]). The number of intact agar beads in the stomach was 7/12 (58%) at 60-minutes and 1/12 (8%) at 120-minutes. Age, bodyweight and sex had measurable effects on gastric function; however, these were small compared to inter-individual variation for most metrics., CONCLUSIONS AND INFERENCES: Reference intervals are presented for MRI measurements of gastric function assessed for the mixed liquid/solid NTM. Studies in patients will determine which metrics are of clinical value and also whether the reference intervals presented here offer optimal diagnostic sensitivity and specificity. Copyright © 2018 John Wiley & Sons Ltd. | |
dc.description.uri | https://dx.doi.org/10.1111/nmo.13463 | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley and Sons Ltd | en_US |
dc.subject | Gastric emptying | en_US |
dc.subject | Magnetic resonance imaging | en_US |
dc.subject | Stomach | en_US |
dc.title | Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects | en_US |
dc.type | Article | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1111/nmo.13463 | en_US |
rioxxterms.type | Journal Article/Review | en_US |
refterms.dateFCD | 2022-10-24T10:07:47Z | |
refterms.versionFCD | VoR | |
refterms.panel | Unspecified | en_US |
refterms.dateFirstOnline | 2018 | |
html.description.abstract | BACKGROUND: Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs)., METHODS: The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads 0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emptying, contraction wave frequency, and secretion were obtained using validated methods., KEY RESULTS: Gastric function was measured in a population of 73 HVs stratified for age and sex. NTM induced moderate satiety and fullness. Labeled fluid was observed in the small bowel in all subjects after meal ingestion ("early-phase" GE). Secretion was rapid such that postprandial gastric content volume was often greater than meal volume (GCV0 > 400 mL), and there was increasing dilution of the meal during the study (P < 0.001). Gastric half-time was median 66-minutes (95% reference interval 35 to 161-minutes "late-phase" GE]). The number of intact agar beads in the stomach was 7/12 (58%) at 60-minutes and 1/12 (8%) at 120-minutes. Age, bodyweight and sex had measurable effects on gastric function; however, these were small compared to inter-individual variation for most metrics., CONCLUSIONS AND INFERENCES: Reference intervals are presented for MRI measurements of gastric function assessed for the mixed liquid/solid NTM. Studies in patients will determine which metrics are of clinical value and also whether the reference intervals presented here offer optimal diagnostic sensitivity and specificity. Copyright © 2018 John Wiley & Sons Ltd. | en_US |
rioxxterms.funder.project | 94a427429a5bcfef7dd04c33360d80cd | en_US |