• Login
    View Item 
    •   Home
    • Nottingham University Hospitals NHS Trust
    • Clinical Support
    • Medical Physics and Clinical Engineering
    • View Item
    •   Home
    • Nottingham University Hospitals NHS Trust
    • Clinical Support
    • Medical Physics and Clinical Engineering
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of EMERCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjectsProfilesView

    My Account

    LoginRegister

    Links

    About EMERPoliciesDerbyshire Community Health Services NHS Foundation TrustLeicester Partnership TrustNHS Nottingham and Nottinghamshire CCGNottinghamshire Healthcare NHS Foundation TrustNottingham University Hospitals NHS TrustSherwood Forest Hospitals NHS Foundation TrustUniversity Hospitals of Derby and Burton NHS Foundation TrustUniversity Hospitals Of Leicester NHS TrustOther Resources

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Evaluation of the implementation of the response assessment in neuro-oncology criteria in the HERBY trial of pediatric patients with newly diagnosed high-grade gliomas

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Evaluation of the implementation ...
    Size:
    1.166Mb
    Format:
    PDF
    Download
    Author
    Rodriguez, Gutierrez D
    Morgan, Paul S
    Jaspan, Tim
    Keyword
    Chemoradiotherapy
    Child
    Glioma
    Neuroimaging
    Date
    2019
    
    Metadata
    Show full item record
    Publisher's URL
    https://dx.doi.org/10.3174/ajnr.A5982
    Abstract
    BACKGROUND AND PURPOSE: HERBY was a Phase II multicenter trial setup to establish the efficacy and safety of adding bevacizumab to radiation therapy and temozolomide in pediatric patients with newly diagnosed non-brain stem high-grade gliomas. This study evaluates the implementation of the radiologic aspects of HERBY., MATERIALS AND METHODS: We analyzed multimodal imaging compliance rates and scan quality for participating sites, adjudication rates and reading times for the central review process, the influence of different Response Assessment in Neuro-Oncology criteria in the final response, the incidence of pseudoprogression, and the benefit of incorporating multimodal imaging into the decision process., RESULTS: Multimodal imaging compliance rates were the following: diffusion, 82%; perfusion, 60%; and spectroscopy, 48%. Neuroradiologists' responses differed for 50% of scans, requiring adjudication, with a total average reading time per patient of approximately 3 hours. Pseudoprogression occurred in 10/116 (9%) cases, 8 in the radiation therapy/temozolomide arm and 2 in the bevacizumab arm (P < .01). Increased target enhancing lesion diameter was a reason for progression in 8/86 cases (9.3%) but never the only radiologic or clinical reason. Event-free survival was predicted earlier in 5/86 (5.8%) patients by multimodal imaging (diffusion, n = 4; perfusion, n = 1)., CONCLUSIONS: The addition of multimodal imaging to the response criteria modified the assessment in a small number of cases, determining progression earlier than structural imaging alone. Increased target lesion diameter, accounting for a large proportion of reading time, was never the only reason to designate disease progression. Copyright © 2019 by American Journal of Neuroradiology.
    Citation
    Rodriguez, D., Chambers, T., Warmuth-Metz, M., Aliaga, E.S., Warren, D., Calmon, R., Hargrave, D., Garcia, J., Vassal, G., Grill, J., Zahlmann, G., Morgan, P.S. and Jaspan, T. (2019) 'Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas', AJNR.American journal of neuroradiology, 40(3), pp. 568-575. doi: https://dx.doi.org/10.3174/ajnr.A5982.
    Publisher
    American Society of Neuroradiology
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15861
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.