• Login
    View Item 
    •   Home
    • Nottingham University Hospitals NHS Trust
    • Clinical Support
    • Medical Physics and Clinical Engineering
    • View Item
    •   Home
    • Nottingham University Hospitals NHS Trust
    • Clinical Support
    • Medical Physics and Clinical Engineering
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of EMERCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjectsProfilesView

    My Account

    LoginRegister

    Links

    About EMERPoliciesDerbyshire Community Health Services NHS Foundation TrustLeicester Partnership TrustNHS Nottingham and Nottinghamshire CCGNottinghamshire Healthcare NHS Foundation TrustNottingham University Hospitals NHS TrustSherwood Forest Hospitals NHS Foundation TrustUniversity Hospitals of Derby and Burton NHS Foundation TrustUniversity Hospitals Of Leicester NHS TrustOther Resources

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: A randomized controlled trial

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Lam, Ching
    Marciani, Luca
    Costigan, Carolyn
    Hoad, Caroline L
    Lingaya, Melanie R
    Banwait, Rawinder
    Spiller, Robin C
    Keyword
    Colon
    Corticotropin-releasing hormone
    Fructose
    Magnetic resonance imaging
    Date
    2016
    
    Metadata
    Show full item record
    Publisher's URL
    https://dx.doi.org/10.3945/ajcn.115.125047
    Abstract
    BACKGROUND: Poorly absorbed fermentable carbohydrates can provoke irritable bowel syndrome (IBS) symptoms by escaping absorption in the small bowel and being rapidly fermented in the colon in some susceptible subjects. IBS patients often are anxious and stressed, and stress accelerates small bowel transit, which may exacerbate malabsorption., OBJECTIVE: In this study we investigated the effect of an intravenous injection of corticotropin-releasing factor (CRF) on fructose malabsorption and the resulting volume of water in the small bowel., DESIGN: We performed a randomized, placebo-controlled crossover study of CRF compared with saline injection in 11 male and 10 female healthy subjects, examining the effect on the malabsorption of a 40-g fructose test meal and its transit through the gut, which was assessed by serial MRI and breath hydrogen measurement. Orocecal transit was assessed with the use of the lactose (13)C]ureide breath test and the adrenal response to CRF was assessed by serial salivary cortisol measurements., RESULTS: CRF injection caused a significant increase in salivary cortisol, which lasted for 135 min. Small bowel water content (SBWC) rose from baseline, peaking at 45 min after fructose ingestion, whereas breath hydrogen peaked later, at 75 min. The area under the curve for SBWC from -15 min to 135 min was significantly lower after CRF compared with saline mean difference: 5911 mL . min (95% CI: 18.4, 11,803 mL . min), P = 0.049]. Considering all subjects, the percentage change in ascending colon volume rose significantly after CRF. This increase was significant for male (P = 0.026), but not female, volunteers., CONCLUSIONS: CRF constricts the small bowel and increases fructose malabsorption, as shown by increased ascending colon volumes. This mechanism may help to explain the increased sensitivity of some stressed individuals to fructose malabsorption. This trial was registered at clinicaltrials.gov as NCT01763281. Copyright © 2016 American Society for Nutrition.
    Citation
    Murray, K.A., Lam, C., Rehman, S., Marciani, L., Costigan, C., Hoad, C.L., Lingaya, M.R., Banwait, R., Bawden, S.J., Gowland, P.A. and Spiller, R.C. (2016) 'Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial', The American Journal of Clinical Nutrition, 103(5), pp. 1318-26. doi: https://dx.doi.org/10.3945/ajcn.115.125047.
    Publisher
    Oxford University Press
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15872
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.