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    Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation

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    Author
    Lam, Ching
    Marciani, Luca
    Costigan, Carolyn
    Hoad, Caroline L
    Spiller, Robin C
    Keyword
    Colon
    Constipation
    Irritable bowel syndrome
    Magnetic resonance imaging
    Date
    2016
    
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    Show full item record
    Publisher's URL
    https://dx.doi.org/10.1111/nmo.12784
    Abstract
    BACKGROUND: Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep( R) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC., METHODS: Twenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning. Following baseline scan, participants ingested 1 L of Moviprep( R) followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h., KEY RESULTS: Weighted average position score for FC was 3.6 (2.5-4.2), significantly greater than IBS-C at 2.0 (1.5-3.2), p = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63-142) mL vs 39 (15-70) mL in IBS-C, p 230 min distinguishes FC from IBS-C with low sensitivity of 55% but high specificity of 95%., CONCLUSION & INFERENCES: Our objective MRI biomarkers allow a distinction between FC and IBS-C. Copyright © 2016 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
    Citation
    Lam, C., Chaddock, G., Marciani, L., Costigan, C., Paul, J., Cox, E., Hoad, C., Menys, A., Pritchard, S., Garsed, K., Taylor, S., Atkinson, D., Gowland, P. and Spiller, R. (2016) 'Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation', Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 28(6), pp. 861-70. doi: https://dx.doi.org/10.1111/nmo.12784.
    Publisher
    John Wiley and Sons Ltd
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/15874
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

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