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dc.contributor.authorPanek, Rafal
dc.date.accessioned2022-10-25T14:42:33Z
dc.date.available2022-10-25T14:42:33Z
dc.date.issued2018
dc.identifier.citationWong, K.H., Panek, R., Dunlop, A., Mcquaid, D., Riddell, A., Welsh, L.C., Murray, I., Koh, D., Leach, M.O., Bhide, S.A., Nutting, C.M., Oyen, W.J., Harrington, K.J. and Newbold, K.L. (2018) 'Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer', European journal of nuclear medicine and molecular imaging, 45(5), pp. 759-767. doi: https://dx.doi.org/10.1007/s00259-017-3890-2.en_US
dc.identifier.issn1619-7089
dc.identifier.urihttp://hdl.handle.net/20.500.12904/15880
dc.description.abstractOBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC)., METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent 18F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation. Patients with evidence of persistent or recurrent disease during follow-up were classed as non-responders. Changes in FMI parameters at week 1 and week 2 were compared between responders and non-responders with the Mann-Whitney U test. The significance threshold was set at a p value of 17%, AUC 0.937)., CONCLUSION: Early intra-treatment changes in FDG-PET, DW and DCE MRI-derived parameters are predictive of ultimate response to chemoradiation in HNSCC. However, the optimal timing for assessment with FDG-PET parameters (week 1) differed from MRI parameters (week 2). This highlighted the importance of scanning time points for the design of FMI risk-stratified interventional studies.
dc.description.urihttps://dx.doi.org/10.1007/s00259-017-3890-2en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectChemoradiotherapyen_US
dc.subjectDiffusion magnetic resonance imagingen_US
dc.subjectHead and neck neoplasmsen_US
dc.titleChanges in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck canceren_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1007/s00259-017-3890-2en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFCD2022-10-25T14:42:34Z
refterms.versionFCDVoR
refterms.dateFOA2022-10-25T14:42:34Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2018
html.description.abstractOBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC)., METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent 18F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation. Patients with evidence of persistent or recurrent disease during follow-up were classed as non-responders. Changes in FMI parameters at week 1 and week 2 were compared between responders and non-responders with the Mann-Whitney U test. The significance threshold was set at a p value of 17%, AUC 0.937)., CONCLUSION: Early intra-treatment changes in FDG-PET, DW and DCE MRI-derived parameters are predictive of ultimate response to chemoradiation in HNSCC. However, the optimal timing for assessment with FDG-PET parameters (week 1) differed from MRI parameters (week 2). This highlighted the importance of scanning time points for the design of FMI risk-stratified interventional studies.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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