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    Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer

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    Author
    Chapman, Caroline J
    Banerjea, Ayan
    Humes, David J
    Ford, Abby
    Hardy, Katie
    Djedovic, Natasha
    Logan, Richard F
    Morling, Joanne R
    Keyword
    Colorectal neoplasms
    Faecal immunochemical testing
    Date
    2021
    
    Metadata
    Show full item record
    Publisher's URL
    https://dx.doi.org/10.1515/cclm-2020-1170
    Abstract
    OBJECTIVES: Currently, NICE recommends the use of faecal immunochemical test (FIT) at faecal haemoglobin concentrations (f-Hb) of 10 mug Hb/g faeces to stratify for colorectal cancer (CRC) risk in symptomatic populations. This f-Hb cut-off is advised across all analysers, despite the fact that a direct comparison of analyser performance, in a clinical setting, has not been performed., METHODS: Two specimen collection devices (OC-Sensor, OC-S; HM-JACKarc, HM-J) were sent to 914 consecutive individuals referred for follow up due to their increased risk of CRC. Agreement of f-Hb around cut-offs of 4, 10 and 150 microg Hb/g faeces and CRC detection rates were assessed. Two OC-S devices were sent to a further 114 individuals, for within test comparisons., RESULTS: A total of 732 (80.1%) individuals correctly completed and returned two different FIT devices, with 38 (5.2%) CRCs detected. Median f-Hb for individuals diagnosed with and without CRC were 258.5 and 1.8 microg Hb/g faeces for OC-S and 318.1 and 1.0 microg Hb/g faeces for HM-J respectively. Correlation of f-Hb results between OC-S/HM-J over the full range was rho=0.74, p<0.001. Using a f-Hb of 4 microg Hb/g faeces for both tests found an agreement of 88.1%, at 10 microg Hb/g faeces 91.7% and at 150 microg Hb/g faeces 96.3%. A total of 114 individuals completed and returned two OC-S devices; correlation across the full range was rho=0.98, p<0.001., CONCLUSIONS: We found large variations in f-Hb when different FIT devices were used, but a smaller variation when the same FIT device was used. Our data suggest that analyser-specific f-Hb cut-offs are applied with regard to clinical decision making, especially at lower f-Hb. Copyright © 2020 Walter de Gruyter GmbH, Berlin/Boston.
    Citation
    Chapman, C.J., Banerjea, A., Humes, D.J., Allen, J., Oliver, S., Ford, A., Hardy, K., Djedovic, N., Logan, R.F. and Morling, J.R. (2021) 'Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer', Clinical Chemistry and Laboratory Medicine, 59(4), pp. 721-728. doi: 10.1515/cclm-2020-1170.
    Publisher
    De Gruyter
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/16094
    Collections
    Medical Physics and Clinical Engineering
    Healthcare Scientists

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