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dc.contributor.authorChapman, Caroline J
dc.date.accessioned2023-01-23T11:26:28Z
dc.date.available2023-01-23T11:26:28Z
dc.identifier.citationKhasawneh, F., Osborne, T., Danaher, P., Barnes, D., Chapman, C.J., Stephenson, J.A. and Singh, B. (2022) 'Faecal immunochemical testing reduces demand and improves yield of Leicester's 2-week pathway for change in bowel habit', Colorectal Disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, . doi: 10.1111/codi.16445.en_US
dc.identifier.issn1463-1318
dc.identifier.urihttp://hdl.handle.net/20.500.12904/16099
dc.description.abstractAim: We look at the effect of introducing the faecal immunochemical test (FIT) in the straight-to-test 2-week pathway for change in bowel habit (CIBH).; Method: The FIT in primary care triages 2-week wait (2WW) colorectal referrals for patients aged 60 years and above for straight-to-test CT colonography (CTC). We compare the impact of the FIT on numbers of 2WW CTCs, in the year before and after FIT, in both colorectal cancer (CRC) detection and cost-effectiveness at both 4 μg Hb/g faeces and 10 μg Hb/g faeces.; Results: At a threshold of 4 μg Hb/g faeces, the positive predictive value of the FIT for diagnosis of CRC is 5.0% with a negative predictive value of 99.8% and a polyp detection rate of 25.5%. The introduction of the FIT resulted in a reduction in the number of CTCs performed through the CIBH pathway from a mean of 143.9 per month prior to the FIT to 66.8 CTCs per month once the FIT was well established. Given a FIT threshold of 10 μg Hb/g the number of CTCs would be predicted to fall by 70.4% to 42.6 CTCs per month resulting in higher CRC and polyp detection rate, and an estimated annual cost saving of £238 258 in our institution.; Conclusion: The FIT use in primary care improves the yield of 2WW referrals for CIBH alone and reduces the burden and cost of investigations to exclude CRC. Improvements may be possible by increasing the cut-off employed, without adversely affecting the risk of missing a cancer.
dc.description.urihttps://doi.org/10.1111/codi.16445en_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.subjectColorectalen_US
dc.subjectFaecal immunochemical testingen_US
dc.titleFaecal immunochemical testing reduces demand and improves yield of Leicester's 2-week pathway for change in bowel habiten_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1111/codi.16445en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFCD2023-01-23T11:26:28Z
refterms.versionFCDVoR
refterms.dateFOA2023-01-23T11:26:28Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2022
html.description.abstractAim: We look at the effect of introducing the faecal immunochemical test (FIT) in the straight-to-test 2-week pathway for change in bowel habit (CIBH).; Method: The FIT in primary care triages 2-week wait (2WW) colorectal referrals for patients aged 60 years and above for straight-to-test CT colonography (CTC). We compare the impact of the FIT on numbers of 2WW CTCs, in the year before and after FIT, in both colorectal cancer (CRC) detection and cost-effectiveness at both 4 μg Hb/g faeces and 10 μg Hb/g faeces.; Results: At a threshold of 4 μg Hb/g faeces, the positive predictive value of the FIT for diagnosis of CRC is 5.0% with a negative predictive value of 99.8% and a polyp detection rate of 25.5%. The introduction of the FIT resulted in a reduction in the number of CTCs performed through the CIBH pathway from a mean of 143.9 per month prior to the FIT to 66.8 CTCs per month once the FIT was well established. Given a FIT threshold of 10 μg Hb/g the number of CTCs would be predicted to fall by 70.4% to 42.6 CTCs per month resulting in higher CRC and polyp detection rate, and an estimated annual cost saving of £238 258 in our institution.; Conclusion: The FIT use in primary care improves the yield of 2WW referrals for CIBH alone and reduces the burden and cost of investigations to exclude CRC. Improvements may be possible by increasing the cut-off employed, without adversely affecting the risk of missing a cancer.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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