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dc.contributor.authorBailey, James A
dc.contributor.authorIbrahim, H
dc.contributor.authorBunce, J
dc.contributor.authorChapman, Caroline J
dc.contributor.authorMorling, Joanne R
dc.contributor.authorSimpson, J
dc.contributor.authorHumes, David J
dc.contributor.authorBanerjea, Ayan
dc.date.accessioned2023-01-23T11:48:06Z
dc.date.available2023-01-23T11:48:06Z
dc.date.issued2021
dc.identifier.citationBailey, J.A., Ibrahim, H., Bunce, J., Chapman, C.J., Morling, J.R., Simpson, J.A., Humes, D.J. and Banerjea, A. (2021) 'Quantitative FIT stratification is superior to NICE referral criteria NG12 in a high-risk colorectal cancer population', Techniques in Coloproctology, 25(10), pp. 1151-1154. doi: 10.1007/s10151-021-02466-z.en_US
dc.identifier.issn1128-045X
dc.identifier.urihttp://hdl.handle.net/20.500.12904/16100
dc.description.abstractBACKGROUND: Guidelines for urgent investigation of colorectal cancer (CRC) are based on age and symptom-based criteria. This study aims to compare the diagnostic value of clinical features and faecal immunochemical test (FIT) results to identify those at a higher risk of CRC, thereby facilitating effective triage of patients., METHODS: We undertook a review of all patients referred for investigation of CRC at our centre between September 2016 and June 2018. Patients were identified using a prospectively recorded local database. We performed a logistic regression analysis of factors associated with a diagnosis of CRC., RESULTS: One-thousand-and-seven-hundred-eighty-four patients with FIT results were included in the study. Change in bowel habit (CIBH) was the most common referring clinical feature (38.3%). Patients diagnosed with CRC were significantly older than those without malignancy (74.0 years vs 68.9 years, p = 0.0007). Male patients were more likely to be diagnosed with CRC than females (6.5% vs 2.5%, Chi-squared 16.93, p = 100 microg Hb/g faeces group (55/181, 30.4%)., CONCLUSION: In a multivariate model, FIT outperforms age, sex and all symptoms prompting referral. FIT has greater stratification value than any referral symptoms. FIT does have value in patients with iron deficiency anaemia. Copyright © 2021. Springer Nature Switzerland AG.
dc.description.urihttps://doi.org/10.1007/s10151-021-02466-zen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectColorectal neoplasmsen_US
dc.subjectFaecal immunochemical testingen_US
dc.titleQuantitative FIT stratification is superior to NICE referral criteria NG12 in a high-risk colorectal cancer populationen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1007/s10151-021-02466-zen_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFCD2023-01-23T11:48:06Z
refterms.versionFCDVoR
refterms.dateFOA2023-01-23T11:48:06Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2021
html.description.abstractBACKGROUND: Guidelines for urgent investigation of colorectal cancer (CRC) are based on age and symptom-based criteria. This study aims to compare the diagnostic value of clinical features and faecal immunochemical test (FIT) results to identify those at a higher risk of CRC, thereby facilitating effective triage of patients., METHODS: We undertook a review of all patients referred for investigation of CRC at our centre between September 2016 and June 2018. Patients were identified using a prospectively recorded local database. We performed a logistic regression analysis of factors associated with a diagnosis of CRC., RESULTS: One-thousand-and-seven-hundred-eighty-four patients with FIT results were included in the study. Change in bowel habit (CIBH) was the most common referring clinical feature (38.3%). Patients diagnosed with CRC were significantly older than those without malignancy (74.0 years vs 68.9 years, p = 0.0007). Male patients were more likely to be diagnosed with CRC than females (6.5% vs 2.5%, Chi-squared 16.93, p = 100 microg Hb/g faeces group (55/181, 30.4%)., CONCLUSION: In a multivariate model, FIT outperforms age, sex and all symptoms prompting referral. FIT has greater stratification value than any referral symptoms. FIT does have value in patients with iron deficiency anaemia. Copyright © 2021. Springer Nature Switzerland AG.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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