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dc.contributor.authorSeehra, Jaspreet
dc.contributor.authorBailey, James A
dc.contributor.authorChapman, Caroline J
dc.contributor.authorMorling, Joanne R
dc.contributor.authorHumes, David J
dc.contributor.authorBanerjea, Ayan
dc.date.accessioned2023-01-23T11:56:44Z
dc.date.available2023-01-23T11:56:44Z
dc.date.issued2021
dc.identifier.citationSeehra, J., Bailey, J., Chapman, C., Morling, J., Humes, D. and Banerjea, A. (2021) 'FIT stratification in the COVID era - Is it safe for rectal bleeding?', British Journal of Surgery, 108, pp. vii104. doi: 10.1093/bjs/znab311.043.en_US
dc.identifier.issn1365-2168
dc.identifier.urihttp://hdl.handle.net/20.500.12904/16101
dc.description.abstractAims: Faecal Immunochemical Tests (FIT) are increasingly used for stratification of colorectal cancer risk in symptomatic patients. FIT is not currently recommended for use in patients with rectal bleeding, but recent studies have reported its safe use. We report our experiences of FIT in patients presenting with rectal bleeding during the COVID-19 pandemic. Method(s): Patients referred to NUH NHS Trust with rectal bleeding from 15/04/20-15/08/20 were invited to complete a postal-based FIT (OCSensor). Demographics, symptoms, investigations and results were recorded. Outcomes were retrospectively reviewed using an electronic hospital system. Result(s): 344 patients were invited to participate, with 301 (87.5%) returning FITs in accordance with testing protocol. 36 patients declined to be seen, 4 were considered not fit for investigation, and 4 had incomplete records. 257 patients were included in the final analysis with 10 CRC detected (3.9%). Rectal bleeding (257, 100%) was the most common presenting symptom followed by change in bowel habit (133, 51.8%). 10 CRC were diagnosed (3.9%). 2 CRC were detected with FIT 100 mug Hb / g faeces (8/45, 17.8%). FIT result was significantly associated with CRC diagnosis (p<0.0001). 4 with CRC had anaemia (4/53, 7.5%), 1 had thrombocytosis (1/12, 8.3%). Conclusion(s): FIT missed 20% of CRC in this patient group with the application of a very low threshold (<4 mug Hb / g faeces). Both cancers missed by FIT were detectable on digital rectal examination, emphasising the importance of this examination in primary care.
dc.description.urihttps://doi.org/10.1093/bjs/znab311.043en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectCOVID-19en_US
dc.subjectFaecal immunochemical testingen_US
dc.titleFIT stratification in the COVID era - Is it safe for rectal bleeding?en_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1093/bjs/znab311.043en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.dateFCD2023-01-23T11:56:45Z
refterms.versionFCDVoR
refterms.dateFOA2023-01-23T11:56:45Z
refterms.panelUnspecifieden_US
refterms.dateFirstOnline2021
html.description.abstractAims: Faecal Immunochemical Tests (FIT) are increasingly used for stratification of colorectal cancer risk in symptomatic patients. FIT is not currently recommended for use in patients with rectal bleeding, but recent studies have reported its safe use. We report our experiences of FIT in patients presenting with rectal bleeding during the COVID-19 pandemic. Method(s): Patients referred to NUH NHS Trust with rectal bleeding from 15/04/20-15/08/20 were invited to complete a postal-based FIT (OCSensor). Demographics, symptoms, investigations and results were recorded. Outcomes were retrospectively reviewed using an electronic hospital system. Result(s): 344 patients were invited to participate, with 301 (87.5%) returning FITs in accordance with testing protocol. 36 patients declined to be seen, 4 were considered not fit for investigation, and 4 had incomplete records. 257 patients were included in the final analysis with 10 CRC detected (3.9%). Rectal bleeding (257, 100%) was the most common presenting symptom followed by change in bowel habit (133, 51.8%). 10 CRC were diagnosed (3.9%). 2 CRC were detected with FIT 100 mug Hb / g faeces (8/45, 17.8%). FIT result was significantly associated with CRC diagnosis (p<0.0001). 4 with CRC had anaemia (4/53, 7.5%), 1 had thrombocytosis (1/12, 8.3%). Conclusion(s): FIT missed 20% of CRC in this patient group with the application of a very low threshold (<4 mug Hb / g faeces). Both cancers missed by FIT were detectable on digital rectal examination, emphasising the importance of this examination in primary care.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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