COVID-19 inpatient treatments and outcomes during the conflict in Syria: an observational cohort study

Abstract

Background: During the COVID-19 pandemic, countries undergoing conflict are having difficulties in mounting an effective health response. In this observational cohort study, we describe the treatment and outcomes of inpatients with COVID-19 in the Syrian city of Latakia. Design and methods: A single-centre observational cohort study was conducted at Tishreen's University hospital involving all patients over 18 admitted between the 1st of October and 31st of December 2021 with positive RT-PCR test for SARS-CoV-2. Clinical features, investigations, treatments and outcomes were reported. Results: A total of 149 patients fit the study criteria. Only one patient was double vaccinated against COVID-19. Oxygen supplementation was required in 87% (n=130) of participants. Invasive mechanical ventilation was required in 4% (n=5). Therapeutic anticoagulation was administered in 97•3% (n=144). Intravenous dexamethasone was received by 97•3% (n=145) of participants. All patients received empiric antibiotics treatment. In-hospital mortality was 48•4% (n=72), whilst only 40•9% (n=61) were discharged home during the study period. Conclusion: The pandemic has pushed a compromised Syrian healthcare system under more significant strain. This requires urgent international relief efforts from health agencies to aid in the pandemics response.