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dc.contributor.authorDavies, Melanie J
dc.date.accessioned2023-11-24T10:06:22Z
dc.date.available2023-11-24T10:06:22Z
dc.date.issued2023-11-01
dc.identifier.citationSathish, T., Khunti, K., Narayan, K. M. V., Mohan, V., Davies, M. J., Yates, T., Oldenburg, B., Thankappan, K. R., Tapp, R. J., Bajpai, R., Anjana, R. M., Weber, M. B., Ali, M. K., & Shaw, J. E. (2023). Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual Participant Data Meta-analysis of Randomized Controlled Trials. Diabetes care, 46(11), 1903–1907. https://doi.org/10.2337/dc23-0696en_US
dc.identifier.other10.2337/dc23-0696
dc.identifier.urihttp://hdl.handle.net/20.500.12904/17909
dc.description.abstractObjective: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype. Research design and methods: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach. Results: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01). Conclusions: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.
dc.description.urihttps://diabetesjournals.org/care/article/46/11/1903/153568/Effect-of-Conventional-Lifestyle-Interventions-onen_US
dc.language.isoenen_US
dc.subjectType 2 Diabetes Incidenceen_US
dc.subjectGlucose-Defined Prediabetes Phenotype:en_US
dc.titleEffect of conventional lifestyle interventions on Type 2 Diabetes incidence by glucose-defined prediabetes phenotype: an individual participant data meta-analysis of randomized controlled trialsen_US
dc.typeArticleen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.versionNAen_US
rioxxterms.versionofrecordhttps://doi.org/10.2337/dc23-0696en_US
rioxxterms.typeJournal Article/Reviewen_US
refterms.panelUnspecifieden_US
html.description.abstractObjective: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype. Research design and methods: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach. Results: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01). Conclusions: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.en_US
rioxxterms.funder.project94a427429a5bcfef7dd04c33360d80cden_US


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