The effect of exercise training on adipose tissue insulin sensitivity: A systematic review and meta-analysis

Abstract

This systematic review and meta-analysis determined the impact of exercise training on adipose tissue insulin sensitivity in adults. Its scope extended to studies measuring whole-body and localized subcutaneous adipose tissue insulin sensitivity using validated techniques. Consensus from four studies demonstrates that exercise training improved whole-body adipose tissue insulin sensitivity when measured via stable-isotope lipid tracers (rate of appearance suppression in response to hyperinsulinemia). Meta-analysis of 20 studies (26 intervention arms) employing the adipose tissue insulin resistance index (ADIPO-IR) supported these findings (-10.63 [-14.12 to -7.15] pmol.L-1 x mmol.L-1). With ADIPO-IR, this response was greater in studies documenting weight loss and shorter sampling time (). With ADIPO-IR, this response was greater in studies documenting weight loss and shorter sampling time (Copyright © 2022 World Obesity Federation.