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    The Impact of Baseline Comorbidities and Performance Status on HER2-Targeted Therapy Outcomes.

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    Author
    Akbari, Amir R
    Keyword
    Comorbitities
    Performance
    Outcomes
    
    Metadata
    Show full item record
    Publisher's URL
    https://www.clinical-breast-cancer.com/article/S1526-8209(24)00368-9/abstract
    Abstract
    We read with great interest the article by Kook et al.,1 comparing adjuvant trastuzumab plus pertuzumab (TP) versus trastuzumab alone (T) in patients with HER2-positive breast cancer who achieved a pathologic complete response (pCR) following neoadjuvant chemotherapy. While the authors concluded that there was no significant difference in recurrence-free survival (RFS) or distant recurrence-free survival (DRFS) between the 2 regimens, we believe the study may have overlooked an important confounding variable: baseline comorbidities and performance status.
    Citation
    Akbari, A.R. and Alam, B. (2025) ‘The Impact of Baseline Comorbidities and Performance Status on HER2-Targeted Therapy Outcomes’, Clinical breast cancer [Preprint].
    Publisher
    Clinical Breast Cancer
    Type
    Article
    URI
    http://hdl.handle.net/20.500.12904/19228
    Collections
    Cancer Services

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