Flowrna in the Diagnosis of EBV-Related Lymphoproliferative Disease
| dc.contributor.author | Jones, Steve | |
| dc.date.accessioned | 2025-03-04T13:36:33Z | |
| dc.date.available | 2025-03-04T13:36:33Z | |
| dc.date.issued | 2023-11 | |
| dc.identifier.citation | Glover, A. et al. (2023) ‘Flowrna in the Diagnosis of EBV-Related Lymphoproliferative Disease’, Blood, 142(Supplement 1), p. 3660 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.12904/19288 | |
| dc.description.abstract | Epstein-Barr (EBV) viraemia is frequently encountered in the context of haemophagocytic lymphohistiocytosis (HLH), systemic inflammation and lymphoproliferative disease (LPD). Although EBV typically infects B lymphocytes triggering both polyclonal proliferation and lymphoma, EBV can also infect T and NK cells. Understanding the phenotype of EBV-infected cells can help identify the underlying diagnosis and guide the use of appropriate targeted therapy. We have developed an EBV FlowRNA assay combining the detection of EBV-encoded small RNA (EBER) with multicolour flow cytometry (Collins, Blood, 2020). Here we present a larger case series illustrating how this assay can be used in diagnostic workup. | |
| dc.description.uri | https://www.sciencedirect.com/science/article/abs/pii/S000649712310262X | en_US |
| dc.publisher | Blood | en_US |
| dc.subject | Epstein-Barr viraemia | en_US |
| dc.subject | (EBV) | en_US |
| dc.subject | Haemophagocytic lymphohistiocytosis | en_US |
| dc.subject | HLH | en_US |
| dc.title | Flowrna in the Diagnosis of EBV-Related Lymphoproliferative Disease | en_US |
| dc.type | Article | en_US |
| rioxxterms.funder | Default funder | en_US |
| rioxxterms.identifier.project | Default project | en_US |
| rioxxterms.version | NA | en_US |
| rioxxterms.versionofrecord | 10.1182/blood-2023-182151 | en_US |
| rioxxterms.type | Journal Article/Review | en_US |
| refterms.dateFOA | 2025-03-04T13:36:34Z | |
| refterms.panel | Unspecified | en_US |
| html.description.abstract | Epstein-Barr (EBV) viraemia is frequently encountered in the context of haemophagocytic lymphohistiocytosis (HLH), systemic inflammation and lymphoproliferative disease (LPD). Although EBV typically infects B lymphocytes triggering both polyclonal proliferation and lymphoma, EBV can also infect T and NK cells. Understanding the phenotype of EBV-infected cells can help identify the underlying diagnosis and guide the use of appropriate targeted therapy. We have developed an EBV FlowRNA assay combining the detection of EBV-encoded small RNA (EBER) with multicolour flow cytometry (Collins, Blood, 2020). Here we present a larger case series illustrating how this assay can be used in diagnostic workup. | en_US |
| rioxxterms.funder.project | 94a427429a5bcfef7dd04c33360d80cd | en_US |
