Recent Submissions

  • Highlighting Risk in Sponsored Studies: A Risk Categorisation Tool

    Skirrow, Sarah; Thornhill, Joanne; Jones, Michael (2019)
  • Quantitative analysis of qualitative information from interviews: A systematic literature review

    Fakis, Apostolos (2014-04)
    Background: A systematic literature review was conducted on mixed methods area. Objectives: The overall aim was to explore how qualitative information from interviews has been analyzed using quantitative methods. Methods: A contemporary review was undertaken and based on a predefined protocol. The references were identified using inclusion and exclusion criteria and specific key terms in 11 search databases. Results: Evidence was synthesized from 14 references that included the methods used for quantifying qualitative information, analyzing it statistically and the rationale behind this. Gaps in the existing literature and recommendations for future research were identified. Conclusions: This review highlights the need for a new mixed method based on advanced statistical modeling method that will explore complex relationships arising from qualitative information.
  • Knowledge, attitude and barriers towards research in the national health service (NHS)

    Ahmed, Mansoor; Boswell, Stephanie (2014-10)
    In the 21st century, healthcare professionals know a great deal about health, disease and medicine. However, much remains uncertain and continued investment in research aims to find better ways of managing patients, improving public health, reducing health inequalities and keeping people in a state of good health. Clinical Research Networks are well established across the NHS to ensure that all patients and clinicians are able to share the benefits of participating in clinical research. Barriers to research can deter healthcare professionals from contributing towards useful research projects. Aim To ascertain knowledge and attitude towards research and identify barriers amongst healthcare professionals in a district general hospital setting. Methods All the healthcare professionals were emailed a questionnaire via 'survey monkey' in March 2014. An email reminder to non-respondents was sent 2 weeks later. Questions focussed on participant's knowledge and attitude towards research and identifying perceived barriers to undertaking research. Results 87 responses were received (26 doctors and 61 allied health professionals). Following table outlines key study findings in %. Conclusions Majority of participants perceived time commitment and bureaucracy as barrier to research. Dedicated time allocated in the job plan and administrative support would be imperative in improving research outcomes leading to innovative treatments that can significantly improve patient health in future.
  • A prospective study of adverse drug reactions to antiepileptic drugs in children.

    Fakis, Apostolos (2015-06)
    Antiepileptic drugs (AEDs) and to prospectively evaluate the effect of AEDs on behaviour. SETTING: A single centre prospective observational study. PARTICIPANTS: Children (<18 years old) receiving one or more AEDs for epilepsy, at each clinically determined follow-up visit. PRIMARY AND SECONDARY OUTCOMES: Primary outcome was adverse reactions of AEDs. Behavioural and cognitive functions were secondary outcomes. RESULTS: 180 children were recruited. Sodium valproate and carbamazepine were the most frequently used AEDs. A total of 114 ADRs were recorded in 56 of these children (31%). 135 children (75%) were on monotherapy. 27 of the 45 children (60%) on polytherapy had ADRs; while 29 (21%) of those on monotherapy had ADRs. The risk of ADRs was significantly lower in patients receiving monotherapy than polytherapy (RR: 0.61, 95% CI 0.47 to 0.79, p<0.0001). Behavioural problems and somnolence were the most common ADRs. 23 children had to discontinue their AED due to an ADR. CONCLUSIONS: Behavioural problems and somnolence were the most common ADRs. Polytherapy significantly increases the likelihood of ADRs in children. TRAIL REGISTRATION NUMBER: EudraCT (2007-000565-37).