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dc.contributor.authorSubramanian, Deepak
dc.date.accessioned2016-08-23T14:51:20Z
dc.date.available2016-08-23T14:51:20Z
dc.date.issued2016-05
dc.identifier.citationEur Respir J. 2016 May 26. pii: ERJ-01878-2015. doi: 10.1183/13993003.01878-2015. [Epub ahead of print]language
dc.identifier.urihttp://hdl.handle.net/20.500.12904/556
dc.descriptionNot Supportedlanguage
dc.description.abstractEvA (Emphysema versus Airway disease) is a multicentre project to study mechanisms and identify biomarkers of emphysema and airway disease in chronic obstructive pulmonary disease (COPD). The objective of this study was to delineate objectively imaging-based emphysema-dominant and airway disease-dominant phenotypes using quantitative computed tomography (QCT) indices, standardised with a novel phantom-based approach.441 subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-3) were assessed in terms of clinical and physiological measurements, laboratory testing and standardised QCT indices of emphysema and airway wall geometry.QCT indices were influenced by scanner non-conformity, but standardisation significantly reduced variability (p<0.001) and led to more robust phenotypes. Four imaging-derived phenotypes were identified, reflecting "emphysema-dominant", "airway disease-dominant", "mixed" disease and "mild" disease. The emphysema-dominant group had significantly higher lung volumes, lower gas transfer coefficient, lower oxygen (PO2 ) and carbon dioxide (PCO2 ) tensions, higher haemoglobin and higher blood leukocyte numbers than the airway disease-dominant group.The utility of QCT for phenotyping in the setting of an international multicentre study is improved by standardisation. QCT indices of emphysema and airway disease can delineate within a population of patients with COPD, phenotypic groups that have typical clinical features known to be associated with emphysema-dominant and airway-dominant disease.language
dc.language.isoenlanguage
dc.subjectCOPDlanguage
dc.subjectComputed Tomographylanguage
dc.subjectEmphysemalanguage
dc.titleEmphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography.language
dc.typeArticlelanguage


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